Nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) in non-small cell lung cancer.,Life Sciences

当前位置： X-MOL 学术 › Life Sci. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) in non-small cell lung cancer.
Life Sciences ( IF 5.2 ) Pub Date : 2020-01-15 , DOI: 10.1016/j.lfs.2020.117325
Zhi Zeng ₁ , Zi-Yao Wang ₂ , Yu-Kun Li ₃ , Dong-Mei Ye ₃ , Juan Zeng ₄ , Jia-Li Hu ₅ , Pi-Feng Chen ₆ , Jiao Xiao ₇ , Juan Zou ₃ , Zhen-Hua Li ₈

Affiliation

Nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) is a transcription factor that can regulate downstream target gene expression. Kelch-like ECH-associated protein 1 (Keap1) negatively regulates Nrf2 activation and translocation to target its 26S proteasomal degradation. It has been widely reported that the Keap1/Nrf2 pathway is associated with tumorigenesis, chemotherapy resistance and progression and development of non-small cell lung cancer (NSCLC). High expression of Nrf2 and low abundance of Keap1 contribute to the abnormalities and unrealistic treatment prognosis of NSCLC. Therefore, elucidating the role and potential mechanism of Nrf2 in NSCLC is essential for understanding tumorigenesis and for the development of strategies for effective clinical management. Here, we summarize current knowledge about the molecular structure and biological function of Nrf2, and we discuss the roles of Nrf2 in tumorigenesis, which will further provide a possible therapeutic strategy for NSCLC.

中文翻译：

非小细胞肺癌中核因子红系2（NF-E2）相关因子2（Nrf2）。

核因子类红细胞2（NF-E2）相关因子2（Nrf2）是可以调节下游靶基因表达的转录因子。凯尔奇样ECH相关蛋白1（Keap1）负调控Nrf2激活和易位，以靶向其26S蛋白酶体降解。广泛报道了Keap1 / Nrf2通路与肿瘤发生，化疗耐药以及非小细胞肺癌（NSCLC）的发展有关。Nrf2的高表达和Keap1的低丰度导致了NSCLC的异常和不切实际的治疗预后。因此，阐明Nrf2在NSCLC中的作用和潜在机制对于理解肿瘤发生和制定有效临床治疗策略至关重要。这里，

更新日期：2020-01-15

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11