BACKGROUND The aim was to estimate the prevalence of frailty and relative contribution of physical/balance, nutritive, cognitive and sensory frailty to important adverse health states (falls, physical activity levels, outdoor mobility, problems in self-care or usual activities, and lack of energy or accomplishment) in an English cohort by age and sex. METHODS Analysis of baseline data from a cohort of 9803 community-dwelling participants in a clinical trial. The sample was drawn from a random selection of all people aged 70 or more registered with 63 general practices across England. Data were collected by postal questionnaire. Frailty was measured with the Strawbridge questionnaire. We used cross sectional, multivariate logistic regression to estimate the association between frailty domains and known correlates and adjusted for age. Some models were stratified by sex. RESULTS Mean age of participants was 78 years (sd 5.7), range 70 to 101 and 47.5% (4653/9803) were men. The prevalence of overall frailty was 20.7% (2005/9671) and there was no difference in prevalence by sex (Odds Ratio 0.98; 95% Confidence Interval 0.89 to 1.08). Sensory frailty was the most common and this was reported by more men (1823/4586) than women (1469/5056; Odds Ratio for sensory frailty 0.62, 95% Confidence Interval 0.57 to 0.68). Men were less likely than women to have physical or nutritive frailty. Physical frailty had the strongest independent associations with adverse health states. However, sensory frailty was independently associated with falls, less frequent walking, problems in self-care and usual activities, lack of energy and accomplishment. CONCLUSIONS Physical frailty was more strongly associated with adverse health states, but sensory frailty was much more common. The health gain from intervention for sensory frailty in England is likely to be substantial, particularly for older men. Sensory frailty should be explored further as an important target of intervention to improve health outcomes for older people both at clinical and population level. TRIAL REGISTRATION ISRCTN71002650.

中文翻译：

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在英格兰基于人口的样本中，不同脆弱域的重要性。

背景技术目的是评估身体虚弱的患病率以及身体/平衡，营养，认知和感觉虚弱对重要不良健康状态（跌倒，体育活动水平，户外活动，自我保健或日常活动中的问题以及缺乏）的相对贡献年龄和性别的英语队列中的能量或成就程度）。方法从临床试验中的9803个社区居民参与者的基线数据中进行分析。该样本是从随机抽取的所有年龄在70岁以上，在英国进行了63次常规治疗的人中选取的。通过邮政调查表收集数据。脆弱性用Strawbridge问卷进行测量。我们使用横截面多元logistic回归估计脆弱域与已知相关性之间的关联，并根据年龄进行了调整。有些模特按性别分层。结果参与者的平均年龄为78岁（5.7 d），范围为70至101，其中47.5％（4653/9803）是男性。总体虚弱的患病率为20.7％（2005/9671），按性别划分的患病率没有差异（几率0.98； 95％可信区间0.89至1.08）。感觉虚弱是最常见的，据报道，男性（1823/4586）多于女性（1469/5056；感觉虚弱的赔率为0.62，95％的置信区间为0.57至0.68）。男性比女性更容易身体虚弱或营养脆弱。身体虚弱与不良健康状况具有最强的独立关联。但是，感觉虚弱与跌倒，步行频率降低，自我保健和日常活动存在问题，精力不足和成就感无关。结论身体虚弱与不良的健康状况密切相关，但感觉虚弱则更为普遍。在英格兰，通过干预身体虚弱而获得的健康收益可能非常可观，尤其是对于老年男性。感官虚弱应作为一种重要的干预目标进行进一步探讨，以改善老年人在临床和人群水平上的健康状况。试用注册号ISRCTN71002650。