We discuss how the efficiency of a chromatography device could be enhanced by incorporating a new feature which ensures flow uniformity. The overall flow of fluid within the device, which has a cuboid shape, could be visualized as a combination of two z patterns. The device is therefore designated as cuboid z2. The reason for flow uniformity is explained using a simple mathematical model, and also based on computational fluid dynamic (CFD) simulations. The cuboid z2 device outperformed its equivalent conventional cylindrical column in terms of separation efficiency metrics such as the number of theoretical plates, the reduced plate height, and attributes of non-interacting tracer solute peaks. The results discussed in this paper clearly indicate the suitability of the cuboid z2 device for carrying out high-resolution chromatographic separations. The z2 flow enhancing feature would also be broadly applicable to any process which requires uniform flow in three-dimensional porous media. In addition to superior fluidic attributes, the cuboid z2 chromatography device has other advantages such as compactness and scalability.

中文翻译：

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流量分配和收集功能可确保色谱设备中可扩展的均匀流量。

我们讨论了如何通过合并确保流量均匀性的新功能来提高色谱设备的效率。装置内流体的总体流动（呈长方体形状）可以可视化为两个z模式的组合。因此，该设备称为长方体z2。使用简单的数学模型并基于计算流体动力学（CFD）模拟来解释流动均匀的原因。长方体z2装置在分离效率指标（例如理论塔板数，降低的塔板高度和非相互作用示踪剂溶质峰的属性）方面优于其等效的常规圆柱色谱柱。本文讨论的结果清楚地表明了长方体z2设备适合进行高分辨率色谱分离。z 2流动增强特征也将广泛应用于需要在三维多孔介质中均匀流动的任何过程。除了优越的流体属性外，长方体z2色谱仪还具有其他优势，例如紧凑性和可扩展性。