Targeted Synthesis of 9‐Azabicyclo[4.2.1]nona‐2,4,7‐trienes by Cobalt(I)‐Catalyzed [6π+2π]‐Cycloaddition of Alkynes to N‐Substituted Azepines and Their Antitumor Activity,European Journal of Organic Chemistry

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Targeted Synthesis of 9‐Azabicyclo[4.2.1]nona‐2,4,7‐trienes by Cobalt(I)‐Catalyzed [6π+2π]‐Cycloaddition of Alkynes to N‐Substituted Azepines and Their Antitumor Activity
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2020-01-27 , DOI: 10.1002/ejoc.201901837
Vladimir A. D'yakonov ₁ , Gulnara N. Kadikova ₁ , Ramil N. Nasretdinov ₁ , Lilya U. Dzhemileva ₁ , Usein M. Dzhemilev ₁

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A broad range of practically valuable substituted 9‐azabicyclo[4.2.1]nona‐2,4,7‐trienes using the reaction of cobalt(I)‐catalyzed [6π+2π]‐cycloaddition of alkynes to N‐carbethoxy(phenoxy)azepines was obtained for the first time. The synthesized 9‐azabicyclo[4.2.1]nona‐2,4,7‐trienes were found to exhibit high antitumor activity in vitro against tumor cell lines.

中文翻译：

钴（I）催化炔烃的[6π+2π]-环加成至N-取代的氮杂物靶向合成9-氮杂双环[4.2.1] nona-2,4,7-三烯及其抗肿瘤活性

利用钴（I）催化炔烃的[6π+2π]-环加成反应到N-乙氧基（苯氧基）反应，广泛地应用了有价值的取代9-氮杂双环[4.2.1] nona-2,4,7-三烯首次获得了阿西平。发现合成的9-氮杂双环[4.2.1] nona-2,4,7-三烯在体外对肿瘤细胞系表现出高抗肿瘤活性。

更新日期：2020-01-27

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