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Targeted Synthesis of 9‐Azabicyclo[4.2.1]nona‐2,4,7‐trienes by Cobalt(I)‐Catalyzed [6π+2π]‐Cycloaddition of Alkynes to N‐Substituted Azepines and Their Antitumor Activity
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2020-01-27 , DOI: 10.1002/ejoc.201901837
Vladimir A. D'yakonov 1 , Gulnara N. Kadikova 1 , Ramil N. Nasretdinov 1 , Lilya U. Dzhemileva 1 , Usein M. Dzhemilev 1
Affiliation  

A broad range of practically valuable substituted 9‐azabicyclo[4.2.1]nona‐2,4,7‐trienes using the reaction of cobalt(I)‐catalyzed [6π+2π]‐cycloaddition of alkynes to N‐carbethoxy(phenoxy)azepines was obtained for the first time. The synthesized 9‐azabicyclo[4.2.1]nona‐2,4,7‐trienes were found to exhibit high antitumor activity in vitro against tumor cell lines.
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中文翻译:

钴(I)催化炔烃的[6π+2π]-环加成至N-取代的氮杂物靶向合成9-氮杂双环[4.2.1] nona-2,4,7-三烯及其抗肿瘤活性

利用钴(I)催化炔烃的[6π+2π]-环加成反应到N-乙氧基(苯氧基)反应,广泛地应用了有价值的取代9-氮杂双环[4.2.1] nona-2,4,7-三烯首次获得了阿西平。发现合成的9-氮杂双环[4.2.1] nona-2,4,7-三烯在体外对肿瘤细胞系表现出高抗肿瘤活性。
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更新日期:2020-01-27
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