Cerebellar Dentate Nucleus functional connectivity with cerebral cortex in Alzheimer’s disease and memory: A seed-based approach,Neurobiology of Aging

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Cerebellar Dentate Nucleus functional connectivity with cerebral cortex in Alzheimer’s disease and memory: A seed-based approach
Neurobiology of Aging ( IF 3.7 ) Pub Date : 2020-05-01 , DOI: 10.1016/j.neurobiolaging.2019.10.026
Giusy Olivito ₁ , Laura Serra ₂ , Camillo Marra ₃ , Carlotta Di Domenico ₂ , Carlo Caltagirone ₄ , Sofia Toniolo ₂ , Mara Cercignani ₅ , Maria Leggio ₆ , Marco Bozzali ₅

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Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by specific patterns of gray and white matter damage and cognitive/behavioral manifestations. The cerebellum has also been implicated in the pathophysiology of AD. Because the cerebellum is known to have strong functional connectivity (FC) with associative cerebral cortex regions, it is possible to hypothesize that it is incorporated into intrinsic FC networks relevant to cognitive manifestation of AD. In the present study, the cerebellar dentate nucleus, the largest cerebellar nucleus and the major output channel to the cerebral cortex, was chosen as the region of interest to test potential cerebellocerebral FC alterations and correlations with patients' memory impairment in a group of patients with AD. Compared to controls, patients with AD showed an increase in FC between the dentate nucleus and regions of the lateral temporal lobe. This study demonstrates that lower memory performances in AD may be related to altered FC within specific cerebellocortical functional modules, thus suggesting the cerebellar contribution to AD pathophysiology and typical memory dysfunctions.

中文翻译：

小脑齿状核与阿尔茨海默病和记忆中大脑皮层的功能连接：一种基于种子的方法

阿尔茨海默病 (AD) 是一种慢性神经退行性疾病，其特征是灰质和白质损伤的特定模式以及认知/行为表现。小脑也与 AD 的病理生理学有关。因为已知小脑与关联的大脑皮层区域具有很强的功能连接 (FC)，所以有可能假设它被纳入与 AD 认知表现相关的内在 FC 网络中。在本研究中，小脑齿状核，最大的小脑核和大脑皮层的主要输出通道，被选为感兴趣的区域，以测试潜在的小脑 FC 改变以及与患者记忆障碍的相关性。广告。与对照相比，AD 患者的齿状核和外侧颞叶区域之间的 FC 增加。这项研究表明，AD 中较低的记忆表现可能与特定小脑皮质功能模块内的 FC 改变有关，从而表明小脑对 AD 病理生理学和典型记忆功能障碍的贡献。

更新日期：2020-05-01

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