Lung epithelium damage in COPD - An unstoppable pathological event?,Cellular Signalling

当前位置： X-MOL 学术 › Cell. Signal. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Lung epithelium damage in COPD - An unstoppable pathological event?
Cellular Signalling ( IF 4.4 ) Pub Date : 2020-01-15 , DOI: 10.1016/j.cellsig.2020.109540
Stefan Hadzic ₁ , Cheng-Yu Wu ₁ , Sergey Avdeev ₂ , Norbert Weissmann ₁ , Ralph Theo Schermuly ₁ , Djuro Kosanovic ₃

Affiliation

Chronic obstructive pulmonary disease (COPD) is a common term for alveolar septal wall destruction resulting in emphysema, and chronic bronchitis accompanied by conductive airway remodelling. In general, this disease is characterized by a disbalance of proteolytic/anti-proteolytic activity, augmented inflammatory response, increased oxidative/nitrosative stress, rise in number of apoptotic cells and decreased proliferation. As the first responder to the various environmental stimuli, epithelium occupies an important position in different lung pathologies, including COPD. Epithelium sequentially transitions from the upper airways in the direction of the gas exchange surface in the alveoli, and every cell type possesses a distinct role in the maintenance of the homeostasis. Basically, a thick ciliated structure of the airway epithelium has a major function in mucus secretion, whereas, alveolar epithelium which forms a thin barrier covered by surfactant has a function in gas exchange. Following this line, we will try to reveal whether or not the chronic bronchitis and emphysema, being two pathological phenotypes in COPD, could originate in two different types of epithelium. In addition, this review focuses on the role of lung epithelium in COPD pathology, and summarises underlying mechanisms and potential therapeutics.

中文翻译：

COPD中的肺上皮损伤-不可阻挡的病理事件？

慢性阻塞性肺疾病（COPD）是肺泡中隔壁破坏导致肺气肿和慢性支气管炎伴有传导性气道重塑的常见术语。通常，该疾病的特征在于蛋白水解/抗蛋白水解活性的失衡，炎症反应增强，氧化/亚硝化应激增加，凋亡细胞数量增加和增殖减少。作为对各种环境刺激的第一反应者，上皮在包括COPD在内的不同肺部疾病中占有重要地位。上皮在肺泡中从上呼吸道沿气体交换表面的方向顺次过渡，并且每种细胞类型在维持体内稳态方面都具有独特的作用。基本上，气道上皮的纤毛纤毛结构在粘液分泌中起主要作用，而形成被表面活性剂覆盖的薄屏障的肺泡上皮在气体交换中起作用。按照这条线，我们将尝试揭示慢性阻塞性肺炎和肺气肿（COPD的两种病理表型）是否可能起源于两种不同类型的上皮细胞。此外，本综述着重于肺上皮在COPD病理中的作用，并总结了潜在的机制和潜在的治疗方法。可能起源于两种不同类型的上皮。此外，本综述着重于肺上皮在COPD病理中的作用，并总结了潜在的机制和潜在的治疗方法。可能起源于两种不同类型的上皮。此外，本综述着重于肺上皮在COPD病理中的作用，并总结了潜在的机制和潜在的治疗方法。

更新日期：2020-01-15

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11