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In Vitro Permeability of Saponins and Sapogenins from Seed Extracts by the Parallel Artificial Membrane Permeability Assay: Effect of in Vitro Gastrointestinal Digestion.
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2020-01-21 , DOI: 10.1021/acs.jafc.9b07182 Joaquin Navarro Del Hierro 1, 2 , Vieri Piazzini 3 , Guillermo Reglero 1, 2, 4 , Diana Martin 1, 2 , Maria Camilla Bergonzi 3
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2020-01-21 , DOI: 10.1021/acs.jafc.9b07182 Joaquin Navarro Del Hierro 1, 2 , Vieri Piazzini 3 , Guillermo Reglero 1, 2, 4 , Diana Martin 1, 2 , Maria Camilla Bergonzi 3
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The permeability of saponins and sapogenins from fenugreek and quinoa extracts, as well as dioscin and diosgenin, was evaluated by the parallel artificial membrane permeability assay (PAMPA). The effect of the digestion process on permeability was determined, with previous development of a gastrointestinal process coupled to PAMPA. Saponins from both seeds displayed a moderate-to-poor permeability (>1 × 10-6 cm/s), although the digestion enhanced their permeability values in the order of 10-5 cm/s (p < 0.001). Sapogenins exhibited a similar permeability to that of saponins, although the digestion enhanced the permeability of sapogenins from quinoa (1.14 ± 0.47 × 10-5 cm/s) but not from fenugreek (2.33 ± 0.99 × 10-6 cm/s). An overall positive impact of coexisting lipids on the permeability was evidenced. PAMPA is shown as a useful, rapid, and easy tool for assessing the permeability of bioactive compounds from complex matrices, with the previous gastrointestinal process being a relevant step.
中文翻译：
平行人工膜通透性测定法从种子提取物中获得的皂苷和皂甙元的体外通透性：胃肠道消化的影响。
胡芦巴和藜麦提取物中的皂苷和皂甙元的渗透性，以及薯os皂素和薯os皂甙元的渗透率，通过平行人工膜渗透率测定（PAMPA）进行了评估。确定了消化过程对通透性的影响，以及先前开发的与PAMPA结合的胃肠道过程。来自两种种子的皂苷显示出中等至差的通透性（> 1×10-6 cm / s），尽管消化将其通透性值提高了约10-5 cm / s（p <0.001）。皂甙元显示出与皂苷相似的通透性，尽管消化增强了藜麦中皂甙元的通透性（1.14±0.47×10-5 cm / s），而胡芦巴中皂甙元的通透性（2.33±0.99×10-6 cm / s）却没有。证明了共存脂质对通透性的总体积极影响。PAMPA显示为有用，快速，
更新日期：2020-01-22
中文翻译：
平行人工膜通透性测定法从种子提取物中获得的皂苷和皂甙元的体外通透性：胃肠道消化的影响。
胡芦巴和藜麦提取物中的皂苷和皂甙元的渗透性，以及薯os皂素和薯os皂甙元的渗透率，通过平行人工膜渗透率测定（PAMPA）进行了评估。确定了消化过程对通透性的影响，以及先前开发的与PAMPA结合的胃肠道过程。来自两种种子的皂苷显示出中等至差的通透性（> 1×10-6 cm / s），尽管消化将其通透性值提高了约10-5 cm / s（p <0.001）。皂甙元显示出与皂苷相似的通透性，尽管消化增强了藜麦中皂甙元的通透性（1.14±0.47×10-5 cm / s），而胡芦巴中皂甙元的通透性（2.33±0.99×10-6 cm / s）却没有。证明了共存脂质对通透性的总体积极影响。PAMPA显示为有用，快速，
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