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Schwarzinicines A-G, 1,4-Diarylbutanoid-Phenethylamine Conjugates from the Leaves of Ficus schwarzii.
Journal of Natural Products ( IF 3.3 ) Pub Date : 2020-01-14 , DOI: 10.1021/acs.jnatprod.9b01160 Premanand Krishnan 1 , Fong-Kai Lee 1 , Veronica Alicia Yap 1 , Yun-Yee Low 2 , Toh-Seok Kam 2 , Kien-Thai Yong 3 , Kang-Nee Ting 1 , Kuan-Hon Lim 1
Journal of Natural Products ( IF 3.3 ) Pub Date : 2020-01-14 , DOI: 10.1021/acs.jnatprod.9b01160 Premanand Krishnan 1 , Fong-Kai Lee 1 , Veronica Alicia Yap 1 , Yun-Yee Low 2 , Toh-Seok Kam 2 , Kien-Thai Yong 3 , Kang-Nee Ting 1 , Kuan-Hon Lim 1
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Schwarzinicines A-G (1-7), representing the first examples of 1,4-diarylbutanoid-phenethylamine conjugates, were isolated from the leaves of Ficus schwarzii. The structures of these compounds were determined by detailed analysis of their MS, 1D and 2D NMR data. Compounds 1-4 exhibited pronounced vasorelaxant effects in the rat isolated aorta (Emax 106-120%; EC50 0.96-2.10 μM). However, compounds 1 and 2 showed no cytotoxic effects against A549, MCF-7, and HCT 116 human cancer cells (IC50 > 10 μM).
中文翻译：
Schwarzinicines AG，1,4-二芳基丁二醛-苯乙胺从无花果叶片上缀合。
Schwarzinicines AG（1-7）是1,4-二芳基丁二醛-苯乙胺偶联物的第一个实例，是从榕树的叶子中分离出来的。这些化合物的结构通过对其MS，1D和2D NMR数据进行详细分析来确定。化合物1-4在大鼠离体主动脉中显示出明显的血管松弛作用（Emax 106-120％; EC50 0.96-2.10μM）。但是，化合物1和2对A549，MCF-7和HCT 116人癌细胞没有细胞毒性作用（IC50> 10μM）。
更新日期：2020-01-15
中文翻译：
Schwarzinicines AG，1,4-二芳基丁二醛-苯乙胺从无花果叶片上缀合。
Schwarzinicines AG（1-7）是1,4-二芳基丁二醛-苯乙胺偶联物的第一个实例，是从榕树的叶子中分离出来的。这些化合物的结构通过对其MS，1D和2D NMR数据进行详细分析来确定。化合物1-4在大鼠离体主动脉中显示出明显的血管松弛作用（Emax 106-120％; EC50 0.96-2.10μM）。但是，化合物1和2对A549，MCF-7和HCT 116人癌细胞没有细胞毒性作用（IC50> 10μM）。
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