The therapeutic dose of small interfering RNA can be reduced by endogenously expressing and packaging the RNA into extracellular vesicles through its integration with the backbone of a highly enriched pre-microRNA.

中文翻译：

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将RNA药物包装到细胞外小泡中。

小干扰RNA的治疗剂量可通过将其与高度富集的pre-microRNA的骨架整合在内源性表达并将其包装到细胞外小泡中来降低。