Perfluorooctanoic acid's (PFOA) widespread use, presence and persistence in the aquatic environment has led to an increasing number of studies focusing on its toxicological effects. In Australia, PFOA has been detected in the aquatic environment, however its effects on Australian native fauna are unknown. In this study, male Australian native fish Murray River rainbowfish (Melanotaenia fluviatilis) were exposed to four different concentrations of PFOA (0.01, 0.1, 1 and 10 mg L-1). Variations in thyroid hormones (Triiodothyronine (T3)/Thyroxine (T4)) and the presence of vitellogenin were determined in plasma. Oxidative stress responses were evaluated in gills and liver. Exposure of male fish to PFOA resulted in altered T3/T4 ratios and the presence of vitellogenin in the plasma. Activities of catalase (CAT) and glutathione- S-transferase (GST) were significantly increased in the gills and significantly reduced in the liver. Lipid peroxidation was observed in both tissues showing that vital organs could not neutralize the peroxides generated by oxidative stress resulting from exposure to PFOA. In natural populations exposed to PFOA, such hormonal disturbances can have negative effects, notably through altered capacity to respond to changes in environmental conditions.

中文翻译：

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全氟辛酸（PFOA）对墨累河彩虹鱼甲状腺状态，卵黄蛋白原和氧化-抗氧化平衡的影响。

全氟辛酸（PFOA）在水生环境中的广泛使用，存在和持久性导致越来越多的研究集中在其毒理学效应上。在澳大利亚，已经在水生环境中检测到PFOA，但是其对澳大利亚本土动物的影响尚不清楚。在这项研究中，雄性澳大利亚本土鱼类墨累河彩虹鱼（Melanotaenia fluviatilis）暴露于四种不同浓度的PFOA（0.01、0.1、1和10 mg L-1）。测定血浆中甲状腺激素（三碘甲状腺素（T3）/甲状腺素（T4））的变化和卵黄蛋白原的存在。评估g和肝脏的氧化应激反应。雄鱼暴露于PFOA会导致T3 / T4比值发生变化，血浆中存在卵黄蛋白原。过ill中的过氧化氢酶（CAT）和谷胱甘肽-S-转移酶（GST）的活性显着增加，肝脏中的活性显着降低。在两个组织中均观察到脂质过氧化，表明重要器官无法中和因暴露于PFOA而产生的氧化应激所产生的过氧化物。在暴露于PFOA的自然种群中，这种荷尔蒙紊乱可能产生负面影响，特别是通过改变对环境条件变化的反应能力。