Metal-Free Regioselective Alkylation of Imidazo[1,2-a]pyridines with N-Hydroxyphthalimide Esters under Organic Photoredox Catalysis,Synlett

当前位置： X-MOL 学术 › Synlett › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Metal-Free Regioselective Alkylation of Imidazo[1,2-a]pyridines with N-Hydroxyphthalimide Esters under Organic Photoredox Catalysis
Synlett ( IF 1.7 ) Pub Date : 2020-01-14 , DOI: 10.1055/s-0039-1691567
Bin Sun _{1,

2} , Tengwei Xu _{2,

3} , Liang Zhang _{2,

3} , Rui Zhu _{2,

3} , Jin Yang _{2,

3} , Min Xu _{1,

2} , Can Jin _{1,

2,

3}

Affiliation

A visible-light-induced direct C–H alkylation of imidazo[1,2-a]pyridines has been developed. It proceeds at room temperature by employing inexpensive Eosin Y as a photocatalyst and alkyl N-hydroxyphthalimide (NHP) esters as alkylation reagents. A variety of NHP esters derived from aliphatic carboxylic acids (primary, secondary, and tertiary) were tolerated in this protocol, giving the corresponding C-5-alkylated products in moderate to excellent yields. Mechanistic studies indicate that a radical decarboxylative coupling pathway was involved in this process.

中文翻译：

有机光氧化还原催化下咪唑并[1,2-a]吡啶与N-羟基邻苯二甲酰亚胺酯的无金属区域选择性烷基化

已开发出可见光诱导的咪唑并 [1,2-a] 吡啶直接 C-H 烷基化。它通过使用廉价的曙红 Y 作为光催化剂和烷基 N-羟基邻苯二甲酰亚胺 (NHP) 酯作为烷基化试剂在室温下进行。该协议允许使用源自脂肪族羧酸（初级、二级和三级）的各种 NHP 酯，从而以中等至极好的收率提供相应的 C-5 烷基化产品。机理研究表明，该过程涉及自由基脱羧偶联途径。

更新日期：2020-01-14

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11