The present study analysed the response of whitefish (Coregonus lavaretus L.) to reduced toxicity after the long-term contamination of subarctic Lake Imandra. High concentrations of Ni, Al, and Sr in fish organs and tissues were accompanied by nephrocalcinosis, scoliosis, and myopathy during the period of intense contamination. After reduction of the toxic impact on the lake, the accumulation of Cu, Al, Sr, Cr, Pb, and Hg in the kidney, which is the target organ for toxicity, was two-fold less and that of Cd was 10-fold less in whitefish from the contaminated part of the lake compared with those in whitefish from the non-contaminated parts of the lake. The ecological success of whitefish from the contaminated part of the lake was associated with the limited accumulation of metals in organs and tissues and a more favourable physiological state compared with whitefish from non-contaminated parts of the lake. Redistribution models were constructed for essential and non-essential metals in the fish liver and kidney depending on the physiological state of fish. The results revealed changes in Fe and Zn metabolism: an increase in Fe and a decrease in Zn accumulation in the liver with increasing stage of liver disease and decreasing blood haemoglobin concentration. Furthermore, under the sub-toxic (except for Cu) conditions of Lake Imandra, the strategy of adaptive fish response is to preserve and maintain acid-base regulation system.

中文翻译：

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鱼类对金属生物富集的反应对减少长期受污染的伊曼德拉湖上的毒性负荷具有反应。

本研究分析了北极暗区伊曼德拉湖长期受到污染后白鱼（Coregonus lavaretus L.）对降低毒性的反应。在鱼类器官和组织中高浓度的Ni，Al和Sr在严重污染期间伴有肾钙化，脊柱侧弯和肌病。减少对湖泊的毒性影响后，作为毒性目标器官的肾脏中的Cu，Al，Sr，Cr，Pb和Hg的积累减少了两倍，而Cd的积累减少了10倍与来自湖泊未受污染地区的白鱼相比，来自湖泊受污染部分的白鱼中的鱼类数量更少。与未经污染的湖泊中的白鱼相比，来自湖泊污染部分的白鱼在生态上的成功与器官和组织中金属的有限积累以及更有利的生理状态有关。根据鱼的生理状态，为鱼肝和肾中的必需和非必需金属建立了重新分配模型。结果揭示了铁和锌代谢的变化：随着肝脏疾病阶段的增加和血红蛋白浓度的降低，肝中铁的增加和锌的积累的减少。此外，在伊曼德拉湖的亚毒性（铜除外）条件下，适应性鱼类反应的策略是保持和维持酸碱调节系统。根据鱼的生理状态，为鱼肝和肾中的必需和非必需金属建立了重新分配模型。结果揭示了铁和锌代谢的变化：随着肝脏疾病阶段的增加和血红蛋白浓度的降低，肝中铁的增加和锌的积累的减少。此外，在伊曼德拉湖的亚毒性（铜除外）条件下，适应性鱼类反应的策略是保持和维持酸碱调节系统。根据鱼的生理状态，为鱼肝和肾中的必需和非必需金属建立了重新分配模型。结果揭示了铁和锌代谢的变化：随着肝脏疾病阶段的增加和血红蛋白浓度的降低，肝中铁的增加和锌的积累的减少。此外，在伊曼德拉湖的亚毒性（铜除外）条件下，适应性鱼类反应的策略是保持和维持酸碱调节系统。随着肝脏疾病阶段的增加和血液中血红蛋白浓度的降低，肝脏中铁的含量增加，锌的积累减少。此外，在伊曼德拉湖的亚毒性（铜除外）条件下，适应性鱼类反应的策略是保持和维持酸碱调节系统。随着肝脏疾病阶段的增加和血液中血红蛋白浓度的降低，肝脏中铁的含量增加，锌的积累减少。此外，在伊曼德拉湖的亚毒性（铜除外）条件下，适应性鱼类反应的策略是保持和维持酸碱调节系统。