BACKGROUND It is believed that deposition of amyloid beta (Aβ) in the brain is the central pathological changes of Alzheimer's disease (AD), which triggers a series of pathological processes. However, the relationship between dyslipidemia and AD is uncertain. Considering the peripheral Aβ levels are related to brain Aβ deposition, we explore the relationships between blood lipids and plasma Aβ. METHODS Participants who lived in the selected village of Xi'an for more than 3 years were enrolled, aged 40-85 years (n = 1282, 37.9% male). Fasting blood lipid, plasma Aβ levels, basic information and living habits were measured. Multiple linear regressions were used. RESULTS In total population, blood lipids were not associated with plasma Aβ. After stratified by blood pressure, serum total cholesterol (TC) and low-density lipoprotein (LDL-c) were positively associated with plasma Aβ42 levels (βTC = 0.666, PTC = 0.024; βLDL-c = 0.743, PLDL-c = 0.011, respectively) in normal blood pressure. LDL-c was negatively associated with plasma Aβ40 levels (β = - 0.986, P = 0.037) in high blood pressure. CONCLUSION Elevated plasma Aβ42 levels are associated with higher TC and LDL-c in normal blood pressure. Elevated plasma Aβ40 levels are associated with lower LDL-c in high blood pressure. This indicated that the relationships between blood lipids and plasma Aβ were confounded by blood pressure.

中文翻译：

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血脂与血浆淀粉样蛋白β之间的关系取决于血压：一项基于人群的横断面研究。

背景技术据信淀粉样蛋白β（Aβ）在脑中的沉积是阿尔茨海默氏病（AD）的主要病理变化，其触发了一系列病理过程。然而，血脂异常与AD之间的关系尚不确定。考虑到外周血Aβ水平与脑Aβ沉积有关，我们探讨了血脂与血浆Aβ之间的关系。方法选择在选定的西安村居住3年以上的参与者，年龄40-85岁（n = 1282，男性37.9％）。测量空腹血脂，血浆Aβ水平，基本信息和生活习惯。使用了多元线性回归。结果在总人群中，血脂与血浆Aβ无关。血压分层后 正常血压下血清总胆固醇（TC）和低密度脂蛋白（LDL-c）与血浆Aβ42水平呈正相关（分别为βTC= 0.666，PTC = 0.024，βLDL-c= 0.743，PLDL-c = 0.011） 。在高血压中，LDL-c与血浆Aβ40水平呈负相关（β=-0.986，P = 0.037）。结论血浆Aβ42水平升高与正常血压下较高的TC和LDL-c有关。血浆Aβ40水平升高与高血压中较低的LDL-c有关。这表明血脂与血浆Aβ之间的关系被血压所混淆。037）处于高血压。结论血浆Aβ42水平升高与正常血压下较高的TC和LDL-c有关。血浆Aβ40水平升高与高血压中较低的LDL-c有关。这表明血脂与血浆Aβ之间的关系被血压所混淆。037）处于高血压。结论血浆Aβ42水平升高与正常血压下较高的TC和LDL-c有关。血浆Aβ40水平升高与高血压中较低的LDL-c有关。这表明血脂与血浆Aβ之间的关系被血压所混淆。