Evaluation of Sponge Metal Catalysts in a Trickle Bed Reactor for the Continuous Hydrogenation of an Aliphatic Nitro Intermediate,Organic Process Research & Development

当前位置： X-MOL 学术 › Org. Process Res. Dev. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Evaluation of Sponge Metal Catalysts in a Trickle Bed Reactor for the Continuous Hydrogenation of an Aliphatic Nitro Intermediate
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2020-01-14 , DOI: 10.1021/acs.oprd.9b00447
Antonella Carangio ₁ , Lee J. Edwards ₁ , Eneritz Fernandez-Puertas ₁ , Jerome F. Hayes ₁ , Maciej M. Kucharski ₁ , Graham W. Rutherford ₂ , Katherine M. P. Wheelhouse ₁ , Glynn D. Williams ₁

Affiliation

Nine sponge nickel catalysts were assessed for the reduction of an aliphatic nitro group in a trickle bed reactor. Focused beam reflectance measurement (FBRM) was used to assess the mechanical strength and particle size distribution of the catalysts. The continuous reduction of (S)-7-methyl-7-(nitromethyl)-1,4-dioxaspiro[4.5]decane was investigated using a Raney nickel catalyst in a fixed bed reactor. The use of a Luna ODiSl temperature probe and an FLIR thermal imaging camera were investigated to monitor the catalyst performance while the process was run. A 1.12 kg sample of the aliphatic nitro compound was reduced to the corresponding amine using a single 20 mL reactor containing 43 g of 3111A Raney nickel over a period of 17 h.

中文翻译：

Tri流床反应器中海绵金属催化剂对脂肪族硝基中间体连续加氢的评价

评估了九种海绵镍催化剂在滴流床反应器中脂肪族硝基的还原。聚焦光束反射率测量（FBRM）用于评估催化剂的机械强度和粒度分布。在固定床反应器中使用阮内镍催化剂研究了（S）-7-甲基-7-（硝基甲基）-1,4-二氧杂螺[4.5]癸烷的连续还原反应。在运行过程中，研究了使用Luna ODiSl温度探针和FLIR热像仪来监控催化剂性能。使用一个含有43 g 3111A拉尼镍的单一20 mL反应器，在17小时内将1.12 kg的脂肪族硝基化合物样品还原为相应的胺。

更新日期：2020-01-14

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11