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Synthesis of Tertiary Benzylic Nitriles via Nickel-Catalyzed Markovnikov Hydrocyanation of α-Substituted Styrenes.
Organic Letters ( IF 4.9 ) Pub Date : 2020-01-14 , DOI: 10.1021/acs.orglett.9b04554 Yidan Xing 1 , Rongrong Yu 1 , Xianjie Fang 1
Organic Letters ( IF 4.9 ) Pub Date : 2020-01-14 , DOI: 10.1021/acs.orglett.9b04554 Yidan Xing 1 , Rongrong Yu 1 , Xianjie Fang 1
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The Markovnikov hydrocyanation of α-substituted styrenes enables the synthesis of tertiary benzylic nitriles under nickel catalysis. The Lewis-acid-free transformation features an unprecedented functional groups tolerance, including the -OH and -NH2 groups. A broad range of tertiary benzylic nitriles were obtained in good to excellent yields. In addition, an asymmetric version of this reaction was preliminarily investigated.
中文翻译：
镍催化的α-取代的苯乙烯的Markovnikov氢氰化反应合成叔苄腈。
α-取代的苯乙烯的马尔科夫尼科夫氢氰化能够在镍催化下合成叔苄腈。无路易斯酸的转化具有前所未有的官能团耐受性，包括-OH和-NH2基团。以良好至优异的产率获得了广泛的叔苄腈。另外，初步研究了该反应的不对称形式。
更新日期：2020-01-15
中文翻译：
镍催化的α-取代的苯乙烯的Markovnikov氢氰化反应合成叔苄腈。
α-取代的苯乙烯的马尔科夫尼科夫氢氰化能够在镍催化下合成叔苄腈。无路易斯酸的转化具有前所未有的官能团耐受性，包括-OH和-NH2基团。以良好至优异的产率获得了广泛的叔苄腈。另外，初步研究了该反应的不对称形式。
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