Catalyzing the Hydrodefluorination of CF3-substituted Alkenes by PhSiH3. H• Transfer from a Nickel Hydride,Journal of the American Chemical Society

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Catalyzing the Hydrodefluorination of CF3-substituted Alkenes by PhSiH3. H• Transfer from a Nickel Hydride
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2020-01-14 , DOI: 10.1021/jacs.9b13757
Chengbo Yao ₁ , Shuai Wang ₁ , Jack Norton ₁ , Matthew Hammond ₁

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The hydrodefluorination of CF3-substituted alkenes can be catalyzed by a nickel(II) hydride bearing a pincer ligand. The cata-lyst loading can be as low as 1 mol%. gem-Difluoroalkenes containing a number of functional groups can be formed in good to excellent yields, by a radical mechanism initiated by H• transfer from the nickel hydride. The relative reactivity of various substrates supports the proposed mechanism, as does a TEMPO trapping experiment.

中文翻译：

PhSiH3催化CF3取代烯烃的加氢脱氟。H• 从镍氢化物转移

CF3 取代烯烃的加氢脱氟可以由带有钳状配体的镍 (II) 氢化物催化。催化剂负载量可以低至 1 mol%。通过从氢化镍中转移 H• 引发的自由基机制，可以以良好到极好的产率形成含有许多官能团的 gem-二氟烯烃。各种底物的相对反应性支持所提出的机制，TEMPO 捕获实验也是如此。

更新日期：2020-01-14

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