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New Chemical Modalities and Strategic Thinking in Early Drug Discovery
ACS Medicinal Chemistry Letters ( IF 3.5 ) Pub Date : 2020-01-14 , DOI: 10.1021/acsmedchemlett.9b00582
Maria-Jesus Blanco 1 , Kevin M. Gardinier 2
Affiliation  

The classical toolbox for drug discovery is continuously expanding beyond traditional small molecules. New chemical modalities including RNA therapeutics, protein degraders, cyclopeptides, antibody drug conjugates, and gene therapy have matured, demonstrating clinical success and are now considered early in target appraisal. In this Viewpoint, we highlight recent progress in the field.

中文翻译:

早期药物发现中的新化学模式和战略思考

用于药物发现的经典工具箱正在不断扩展,超越传统的小分子。包括RNA疗法,蛋白质降解剂,环肽,抗体药物结合物和基因疗法在内的新化学方法已经成熟,证明了临床上的成功,现在被认为在目标评估的早期。在此观点中,我们重点介绍了该领域的最新进展。
更新日期:2020-01-15
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