Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Neuroinflammation-Associated Aspecific Manipulation of Mouse Predator Fear by Toxoplasma gondii.
Cell Reports ( IF 7.5 ) Pub Date : 2020-01-14 , DOI: 10.1016/j.celrep.2019.12.019 Madlaina Boillat 1 , Pierre-Mehdi Hammoudi 2 , Sunil Kumar Dogga 2 , Stéphane Pagès 3 , Maged Goubran 4 , Ivan Rodriguez 1 , Dominique Soldati-Favre 2
Cell Reports ( IF 7.5 ) Pub Date : 2020-01-14 , DOI: 10.1016/j.celrep.2019.12.019 Madlaina Boillat 1 , Pierre-Mehdi Hammoudi 2 , Sunil Kumar Dogga 2 , Stéphane Pagès 3 , Maged Goubran 4 , Ivan Rodriguez 1 , Dominique Soldati-Favre 2
Affiliation
|
In rodents, the decrease of felid aversion induced by Toxoplasma gondii, a phenomenon termed fatal attraction, is interpreted as an adaptive manipulation by the neurotropic protozoan parasite. With the aim of understanding how the parasite induces such specific behavioral modifications, we performed a multiparametric analysis of T. gondii-induced changes on host behavior, physiology, and brain transcriptome as well as parasite cyst load and distribution. Using a set of complementary behavioral tests, we provide strong evidence that T. gondii lowers general anxiety in infected mice, increases explorative behaviors, and surprisingly alters predator aversion without selectivity toward felids. Furthermore, we show a positive correlation between the severity of the behavioral alterations and the cyst load, which indirectly reflects the level of inflammation during brain colonization. Taken together, these findings refute the myth of a selective loss of cat fear in T. gondii-infected mice and point toward widespread immune-related alterations of behaviors.
中文翻译：
弓形虫对小鼠捕食者恐惧的神经炎症相关非特异性操纵。
在啮齿动物中，弓形虫引起的猫科动物厌恶感的减少（一种称为致命吸引力的现象）被解释为嗜神经原生动物寄生虫的适应性操纵。为了了解寄生虫如何诱导这种特定的行为改变，我们对弓形虫引起的宿主行为、生理和大脑转录组以及寄生虫包囊负载和分布的变化进行了多参数分析。通过一系列补充行为测试，我们提供了强有力的证据，证明弓形虫可以降低受感染小鼠的普遍焦虑，增加探索行为，并令人惊讶地改变捕食者的厌恶，而无需对猫科动物进行选择性。此外，我们发现行为改变的严重程度与囊肿负荷之间呈正相关，这间接反映了大脑定植期间的炎症水平。总而言之，这些发现驳斥了感染弓形虫的小鼠选择性丧失对猫的恐惧的神话，并指出了广泛的与免疫相关的行为改变。
更新日期：2020-01-15
中文翻译：
弓形虫对小鼠捕食者恐惧的神经炎症相关非特异性操纵。
在啮齿动物中，弓形虫引起的猫科动物厌恶感的减少（一种称为致命吸引力的现象）被解释为嗜神经原生动物寄生虫的适应性操纵。为了了解寄生虫如何诱导这种特定的行为改变，我们对弓形虫引起的宿主行为、生理和大脑转录组以及寄生虫包囊负载和分布的变化进行了多参数分析。通过一系列补充行为测试，我们提供了强有力的证据，证明弓形虫可以降低受感染小鼠的普遍焦虑，增加探索行为，并令人惊讶地改变捕食者的厌恶，而无需对猫科动物进行选择性。此外，我们发现行为改变的严重程度与囊肿负荷之间呈正相关，这间接反映了大脑定植期间的炎症水平。总而言之，这些发现驳斥了感染弓形虫的小鼠选择性丧失对猫的恐惧的神话，并指出了广泛的与免疫相关的行为改变。
京公网安备 11010802027423号