Sensing tissue damage is an ancient function of immune cells that is central to the regulation of inflammation, tissue repair, and immunity. In this issue of Immunity, Lai et al. (2020) uncover a role for the C-type lectin receptor Clec2d as a sensor of cell death, which directly detects histones released during necrosis and thus contributes to inflammation and immunopathology.

中文翻译：

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Clec2d加入了细胞死亡传感器的行列。

感知组织损伤是免疫细胞的一项古老功能，对调节炎症，修复组织和免疫至关重要。在本期《免疫》中，赖等人。（2020）发现C型凝集素受体Clec2d作为细胞死亡的传感器，可直接检测坏死过程中释放的组蛋白，从而有助于炎症和免疫病理学。