Background To determine normative data by forced oscillation technique (FOT) in non-sedated normal term neonates and test the hypothesis that infants with transient tachypnea of the newborn (TTN) have higher resistance ( R ) and lower reactance ( X ) on day 1. Methods Healthy term infants ( n = 138) and infants with TTN ( n = 17) were evaluated on postnatal days 1 through 3 (NCT03346343). FOT was measured with a mask using a TremoFlo C-100 Airwave System™. R , X , and area under the reactance curve (AX) were measured at prime frequencies 7–41 Hz for 8 s. Results In all, 86% of control infants had adequate measurements (coherence >0.8, CV < 0.25) on day 1. Infants with TTN had higher resistance at 13 Hz (TTN 32.5 cm H 2 O·s/L [95% CI 25.5–39.4]; controls 23.8 cm H 2 O·s/L [95% CI 22.2 to 25.3], P = 0.007) and lower reactance from 17 to 37 Hz (TTN −35.1 to −10.5; controls −26.3 to −6.1, P < 0.05). In healthy controls, lung mechanics were unchanged from days 1 to 3. In TTN, lung mechanics normalized on days 2 and 3. Conclusions FOT is feasible in neonates and distinguishes normal control infants from those with TTN on postnatal day 1. Oscillometry offers a non-invasive, longitudinal technique to assess lung mechanics in newborns.

中文翻译：

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非侵入性强制示波法量化足月新生儿的呼吸力学

背景 通过强制振荡技术 (FOT) 确定非镇静正常足月新生儿的规范数据，并检验新生儿短暂性呼吸急促 (TTN) 婴儿在第 1 天具有较高阻力 (R) 和较低电抗 (X) 的假设。方法 健康足月婴儿 (n = 138) 和 TTN 婴儿 (n = 17) 在出生后第 1 天至第 3 天 (NCT03346343) 进行评估。使用 TremoFlo C-100 Airwave System™ 使用面罩测量 FOT。R、X 和电抗曲线下面积 (AX) 在 7-41 Hz 的主频率下测量 8 秒。结果 总之，86% 的对照婴儿在第 1 天进行了充分的测量（相关性 >0.8，CV < 0.25）。TTN 婴儿在 13 Hz 时具有更高的电阻（TTN 32.5 cm H 2 O·s/L [95% CI 25.5 –39.4]；控制 23.8 cm H 2 O·s/L [95% CI 22.2 至 25.3]，P = 0。007）和从 17 到 37 Hz 的较低电抗（TTN -35.1 到 -10.5；控制 -26.3 到 -6.1，P < 0.05）。在健康对照组中，肺力学从第 1 天到第 3 天没有变化。在 TTN 中，肺力学在第 2 天和第 3 天恢复正常。结论 FOT 在新生儿中是可行的，并在出生后第 1 天区分正常对照婴儿和 TTN 婴儿。示波法提供了一种非-评估新生儿肺力学的侵入性纵向技术。