Increased plasma CD14 levels 1 year postpartum in women with pre-eclampsia during pregnancy: a case-control plasma proteomics study.,Nutrition & Diabetes

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Increased plasma CD14 levels 1 year postpartum in women with pre-eclampsia during pregnancy: a case-control plasma proteomics study.
Nutrition & Diabetes ( IF 4.6 ) Pub Date : 2020-01-14 , DOI: 10.1038/s41387-019-0105-x
Antigoni Manousopoulou ₁ , Fatma S Abad ₂ , Diana J Garay-Baquero ₃ , Brian R Birch ₄ , Bas B van Rijn ₅ , Bashir A Lwaleed ₂ , Spiros D Garbis _{4,

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Affiliation

Epidemiological data suggest that pre-eclampsia (PE) is associated with an increased risk of post-delivery metabolic dysregulation. The aim of the present case-control observational study was to examine the global plasma proteomic profile 1 year postpartum in women who developed PE during pregnancy (n = 5) compared to controls (n = 5), in order to identify a novel predictive marker linking PE with long-term metabolic imbalance. Key findings were verified with enzyme-linked immunosorbent assay (ELISA) in a separate cohort (n = 17 women with PE and n = 43 controls). One hundred and seventy-two proteins were differentially expressed in the PE vs. control groups. Gene ontology analysis showed that Inflammatory|Immune responses, Blood coagulation and Metabolism were significantly enriched terms. CD14, mapping to the inflammatory response protein network, was selected for verification based on bibliographic evidence. ELISA measurements showed CD14 to be significantly increased 1 year postpartum in women with PE during pregnancy compared to controls [PE group (median ± SD): 296.5 ± 113.6; control group (median ± SD): 128.9 ± 98.5; Mann-Whitney U test p = 0.0078]. Overall, the identified proteins could provide insight into the long-term disease risk among women with PE during pregnancy and highlight the need for their postpartum monitoring. CD14 could be examined in larger cohorts as a predictive marker of insulin resistance and type II diabetes mellitus among women with PE.

中文翻译：

妊娠先兆子痫妇女产后1年血浆CD14水平升高：一项病例对照血浆蛋白质组学研究。

流行病学数据表明，先兆子痫（PE）与分娩后代谢异常的风险增加有关。本病例对照观察性研究的目的是检查与对照组（n = 5）相比，妊娠期间发生PE（n = 5）的妇女在产后1年的总体血浆蛋白组学特征，以鉴定新的预测标记将PE与长期代谢失衡联系起来。在一个独立的队列中（n = 17名患有PE的女性和n = 43个对照），通过酶联免疫吸附测定（ELISA）验证了主要发现。PE与对照组相比，有172个蛋白质差异表达。基因本体论分析表明，炎症反应，凝血和代谢显着丰富。CD14，根据书目证据，选择定位到炎症反应蛋白网络的定位图进行验证。ELISA测量显示，与对照组相比，PE孕妇在妊娠1年后CD14明显增加[PE组（中位数±SD）：296.5±113.6；对照组（中位±SD）：128.9±98.5; Mann-Whitney U检验p = 0.0078]。总体而言，鉴定出的蛋白质可以提供对妊娠期PE妇女长期疾病风险的了解，并突出说明其产后监测的必要性。CD14可以在更大的队列中进行检查，作为PE妇女中胰岛素抵抗和II型糖尿病的预测指标。ELISA测量显示，与对照组相比，PE孕妇在妊娠1年后CD14明显增加[PE组（中位数±SD）：296.5±113.6；对照组（中位±SD）：128.9±98.5; Mann-Whitney U检验p = 0.0078]。总体而言，鉴定出的蛋白质可以提供对妊娠期PE妇女长期疾病风险的了解，并强调需要对其产后进行监测。CD14可以作为PE妇女中胰岛素抵抗和II型糖尿病的预测指标进行更大规模的研究。ELISA测量显示，与对照组相比，PE孕妇在妊娠1年后CD14明显增加[PE组（中位数±SD）：296.5±113.6；对照组（中位±SD）：128.9±98.5; Mann-Whitney U检验p = 0.0078]。总体而言，鉴定出的蛋白质可以提供对妊娠期PE妇女长期疾病风险的了解，并强调需要对其产后进行监测。CD14可以作为PE妇女中胰岛素抵抗和II型糖尿病的预测指标进行更大规模的研究。鉴定出的蛋白质可以提供对妊娠期PE妇女长期疾病风险的了解，并强调需要对其产后进行监测。CD14可以作为PE妇女中胰岛素抵抗和II型糖尿病的预测指标进行更大规模的研究。鉴定出的蛋白质可以提供对妊娠期PE妇女长期疾病风险的了解，并强调需要对其产后进行监测。CD14可以在更大的队列中进行检查，作为PE妇女中胰岛素抵抗和II型糖尿病的预测指标。

更新日期：2020-01-14

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