Maternal and fetal gene variants play important roles in the pathology of pre-eclampsia (PE), but most studies investigating the associations between vascular endothelial growth factor A (VEGF-A) gene variates and PE focusing on maternal genetic effects. The present study firstly used a hybrid case-parent and control-mother study design investigating the both maternal and fetal effects of VEGF-A gene polymorphisms on PE among Han Chinese pregnant women. This study recruited 221 PE patients with their partners and infants and 345 normotensive women with their infants. The current study found that, in both maternal and fetal dominant model (GC + CC/GG), VEGF-A rs2010963 polymorphism was associated with an increased risk of PE (OR = 1.85, 95% CI: 1.25-2.75; OR = 1.90, 95% CI: 1.28-2.83, respectively). In the log-liner model analyses, offspring carrying the genotype of GC or CC in the rs2010963 polymorphism could increase the risk of maternal PE (OR = 1.84, 95%CI: 1.18-2.86; OR = 1.89, 95%CI: 1.02-3.49, respectively) compared to the offspring with GG. Meanwhile, the present study also found that passive smoking had a significant interaction with maternal rs2010963 polymorphism (PLRT = 0.022) on the risk of PE.

中文翻译：

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母胎血管内皮生长因子单核苷酸多态性对先兆子痫的影响：一项混合设计研究

母体和胎儿基因变异在先兆子痫 (PE) 的病理学中发挥重要作用，但大多数研究血管内皮生长因子 A (VEGF-A) 基因变异与 PE 之间的关联的研究侧重于母体遗传效应。本研究首先使用病例-父母和对照-母亲的混合研究设计，调查 VEGF-A 基因多态性对汉族孕妇 PE 的母婴影响。该研究招募了 221 名 PE 患者及其伴侣和婴儿，以及 345 名血压正常的女性及其婴儿。目前的研究发现，在母胎显性模型（GC+CC/GG）中，VEGF-A rs2010963 多态性与 PE 风险增加相关（OR = 1.85，95% CI：1.25-2.75；OR = 1.90 , 95% CI：分别为 1.28-2.83)。在对数线性模型分析中，与后代相比，在 rs2010963 多态性中携带 GC 或 CC 基因型的后代可能会增加母体 PE 的风险（OR = 1.84，95%CI：1.18-2.86；OR = 1.89，95%CI：1.02-3.49，分别）与GG。同时，本研究还发现，被动吸烟与母亲 rs2010963 多态性（PLRT = 0.022）对 PE 风险有显着交互作用。