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Mitochondrial localization of NCXs: Balancing calcium and energy homeostasis.
Cell Calcium ( IF 4.3 ) Pub Date : 2020-01-14 , DOI: 10.1016/j.ceca.2020.102162 Simona Magi 1 , Silvia Piccirillo 1 , Alessandra Preziuso 1 , Salvatore Amoroso 1 , Vincenzo Lariccia 1
Cell Calcium ( IF 4.3 ) Pub Date : 2020-01-14 , DOI: 10.1016/j.ceca.2020.102162 Simona Magi 1 , Silvia Piccirillo 1 , Alessandra Preziuso 1 , Salvatore Amoroso 1 , Vincenzo Lariccia 1
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It is well established that mitochondria are the main source of ATP production within cells. However, mitochondria have other remarkable functions, serving as important modulators of cellular Ca2+ signaling, and it is now generally recognized that control over Ca2+ homeostasis is intrinsically interwoven with mitochondrial abilities to adjust and tune ATP production. In this review, we describe the mechanisms that mitochondria use to balance Ca2+ homeostasis maintenance and cell energy metabolism. In recent years, the knowledge on the molecular machinery mediating Ca2+ influx/efflux has been improved and, albeit still open to further investigations, several lines of evidence converge on the hypothesis that plasma membrane Na+/Ca2+ exchanger (NCX) isoforms are also expressed at the mitochondrial level, where they contribute to the Ca2+ and Na+ homeostasis maintenance. In particular, the connection between mitochondrial NCX activity and metabolic substrates utilization is further discussed here. We also briefly focus on the alterations of both mitochondrial Ca2+ handling and cellular bioenergetics in neurodegenerative diseases, such as Parkinson's and Alzheimer's disease.
中文翻译：
NCX的线粒体定位：平衡钙和能量稳态。
众所周知，线粒体是细胞内ATP产生的主要来源。然而，线粒体还具有其他显着功能，是细胞Ca2 +信号传导的重要调节剂，现在人们普遍认识到，控制Ca2 +稳态与线粒体调节和调节ATP产生的能力是内在交织的。在这篇综述中，我们描述了线粒体用来平衡Ca2 +稳态维持和细胞能量代谢的机制。近年来，关于介导Ca 2+流入/流出的分子机制的知识已经得到了改进，尽管仍然有待进一步研究，但在质膜Na + / Ca 2+交换子（NCX）同工型也表达于这一假说的前提下，有几条证据相一致。线粒体水平 它们有助于维持Ca2 +和Na +稳态。特别是，在这里进一步讨论了线粒体NCX活性和代谢底物利用之间的联系。我们还简要介绍了神经退行性疾病（如帕金森氏症和阿尔茨海默氏病）中线粒体Ca2 +处理和细胞生物能学的变化。
更新日期：2020-01-14
中文翻译：
NCX的线粒体定位：平衡钙和能量稳态。
众所周知，线粒体是细胞内ATP产生的主要来源。然而，线粒体还具有其他显着功能，是细胞Ca2 +信号传导的重要调节剂，现在人们普遍认识到，控制Ca2 +稳态与线粒体调节和调节ATP产生的能力是内在交织的。在这篇综述中，我们描述了线粒体用来平衡Ca2 +稳态维持和细胞能量代谢的机制。近年来，关于介导Ca 2+流入/流出的分子机制的知识已经得到了改进，尽管仍然有待进一步研究，但在质膜Na + / Ca 2+交换子（NCX）同工型也表达于这一假说的前提下，有几条证据相一致。线粒体水平 它们有助于维持Ca2 +和Na +稳态。特别是，在这里进一步讨论了线粒体NCX活性和代谢底物利用之间的联系。我们还简要介绍了神经退行性疾病（如帕金森氏症和阿尔茨海默氏病）中线粒体Ca2 +处理和细胞生物能学的变化。
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