A new lasso peptide, huascopeptin, was isolated following genome-mined discovery of a new biosynthetic gene cluster in extremotolerant Streptomyces huasconensis HST28T from Salar de Huasco, Atacama Desert, Chile. Compound 1 is a 13-residue class II lasso peptide containing a novel Gly1-Asp7 macrolactam ring, a three-residue loop, and a three-residue tail, making it the smallest lasso peptide isolated to date. The lasso structure was confirmed using NOE restraint-based molecular dynamics simulations.

中文翻译：

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缩小II类套索肽的尺寸：包含第一个Gly1-Asp7大环的Huascopeptin的基因组引导分离。

在智利阿塔卡马沙漠萨拉尔德华斯科的极端耐链霉菌链霉菌HST28T的基因组挖掘发现新的生物合成基因簇之后，分离了一种新的套索肽huascopeptin。化合物1是13个残基的II类套索肽，包含一个新的Gly1-Asp7大内酰胺环，一个3个残基的环和一个3个残基的尾巴，是迄今为止分离出的最小的套索肽。套索结构使用基于NOE约束的分子动力学模拟得到证实。