Skin is the largest barrier organ and an important interface between the body and the outside environment. Immune surveillance and homeostatic regulation of skin function are governed by complex interactions between resident lymphoid and myeloid cells and their communications with the surrounding parenchyma. Recent studies have provided exciting insights about the unique characteristics of skin-resident innate lymphoid cells (ILCs). Here, we discuss advances demonstrating how skin ILCs contribute to tissue homeostasis by regulating microbiome balance in steady-state and how their dysregulation can trigger and promote inflammatory skin diseases such as atopic dermatitis and psoriasis. We review the phenotypic and functional similarities and differences of ILCs between the skin and other organs and highlight future areas of investigation for this field.

中文翻译：

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皮肤常驻先天淋巴样细胞-皮肤先天监护人和调节剂。

皮肤是最大的屏障器官，是人体与外界环境之间的重要界面。免疫监视和皮肤功能的稳态调节受常驻淋巴和髓样细胞之间复杂的相互作用以及它们与周围薄壁组织的通讯的控制。最近的研究提供了有关皮肤固有先天性淋巴样细胞（ILC）独特特征的令人兴奋的见解。在这里，我们讨论了一些进展，这些进展说明了皮肤ILC如何通过调节稳态下的微生物组平衡来促进组织稳态，以及它们的失调如何触发和促进炎症性皮肤病，如特应性皮炎和牛皮癣。