BACKGROUND Metabolic disorders of glucose and lipid were associated with some mineral elements, and data were warranted from various contexts to make the association more explicit. OBJECTIVE To investigate the relationships between the serum concentrations of six mineral elements (calcium, cobalt, copper, iron, magnesium, and selenium) and the risk of hyperglycemia and dyslipidemia in adults. METHODS The basic information and the over-night fasting serum samples of adults were randomly collected at a health examination center. The serum concentrations of glucose and lipids were measured with an automatic biochemical analyzer, and the mineral elements were measured with an inductively coupled plasma mass spectrometer. Data were analyzed between the hyperglycemia group (HGg) and the normal glucose group (NGg) as well as between the dyslipidemia group (DLg) and the normal lipid group (NLg). RESULTS A total of 1466 adults aged 22-81 years (male/female = 1.8) were included, 110 in the HGg and 1356 in the NGg, or 873 in the DLg and 593 in the NLg. The serum element concentration medians [P50 (P25-P75)] significantly different between the HGg and the NGg were 0.83 (0.75-0.94) vs. 0.76 (0.68-0.87) mg/L for copper and 100 (90-110) vs. 94 (87-103) μg/L for selenium (P < 0.001), while those between the DLg and the NLg were 99 (92-110) vs. 97 (90-106) mg/L for calcium, 0.78 (0.69-0.88) vs. 0.75 (0.66-0.85) mg/L for copper, 1.7 (1.4-2.0) vs. 1.6 (1.3-2.0) mg/L for iron, 24 (22-28) vs. 23 (22-27) mg/L for magnesium, and 97 (89-106) vs. 92 (84-100) μg/L for selenium (P < 0.05). When the copper and selenium between the HGg and the NGg were analyzed by logistic regression with age, gender, body mass index, and mineral elements adjusted, only the highest quartile of selenium concentration had association with the increased risk of hyperglycemia [quartile (Q) 4 against Q1: OR = 2.9, 95 % CI = 1.5-5.5, P < 0.001). When the five differed mineral elements between the DLg and the NLg were similarly analyzed, only iron and selenium had associations with the increased risk of dyslipidemia (e.g., Q4 against Q1: OR = 1.4, 95 % CI = 1.1-2.0 for iron and OR = 2.9, 95 % CI = 2.1-4.0 for selenium, P < 0.05). CONCLUSION In contrast to those of calcium, cobalt, copper, iron, and magnesium, the higher serum concentration of selenium increased the risk of both hyperglycemia and dyslipidemia in the study population of adult Chinese.

中文翻译：

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血清中硒的高浓度而不是钙，钴，铜，铁和镁的高浓度会增加成人高血糖和血脂异常的风险：一项基于健康检查中心的横断面研究。

背景技术葡萄糖和脂质的代谢紊乱与某些矿物质元素有关，并且有必要从各种情况中获得数据，以使这种关联更加明确。目的探讨成人六种矿物质元素（钙，钴，铜，铁，镁和硒）的血清浓度与高血糖和血脂异常风险之间的关系。方法在健康检查中心随机采集成年人的基本信息和过夜空腹血清样本。用自动生化分析仪测量血清葡萄糖和脂质的浓度，用感应耦合等离子体质谱仪测量矿质元素。分析了高血糖组（HGg）和正常葡萄糖组（NGg）之间的数据，以及血脂异常组（DLg）和正常脂质组（NLg）之间的数据。结果共纳入1466​​名22-81岁（男性/女性= 1.8）的成年人，其中HGg组110名，NGg组1356名，DLg组873名，NLg组593名。HGg和NGg之间的血清元素浓度中位数[P50（P25-P75）]显着不同，铜为0.83（0.75-0.94）vs. 0.76（0.68-0.87）mg / L，而铜为100（90-110）。硒为94（87-103）μg/ L（P <0.001），而DLg和NLg之间为99（92-110）vs.钙为97（90-106）mg / L，0.78（0.69-铜为0.88）vs.0.75（0.66-0.85）mg / L，铁为1.7（1.4-2.0）vs.1.6（1.3-2.0）mg / L，24（22-28）vs.23（22-27）镁的mg / L和97（89-106）vs. 硒为92（84-100）μg/ L（P <0.05）。当通过年龄，性别，体重指数和矿物质元素进行logistic回归分析对HGg和NGg之间的铜和硒进行分析时，只有最高硒浓度的四分位数与高血糖风险增加相关[四分位数（Q）相对于Q1为4：OR = 2.9，95％CI = 1.5-5.5，P <0.001）。当对DLg和NLg之间的五个不同矿物质元素进行类似分析时，只有铁和硒与血脂异常风险增加相关（例如，Q4对Q1：OR = 1.4，95％CI = 1.1-2.0（对于铁和OR） = 2.9，硒的95％CI = 2.1-4.0，P <0.05）。结论与钙，钴，铜，铁和镁相比，