Reward processing impairments have been linked with positive and negative symptoms of schizophrenia. Here, we performed a coordinate-based meta-analysis that combined eleven BOLD-fMRI studies comparing reward anticipation signals between schizophrenia patients and healthy controls. We observed a reduced difference in activation in schizophrenia patients within a frontal-striatal network. Meta-regressions revealed that this functional signature was linked to the severity of psychotic symptoms and persisted even after controlling for the dose of antipsychotic medications.

中文翻译：

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精神分裂症的奖励预期：基于坐标的荟萃分析

奖励处理障碍与精神分裂症的阳性和阴性症状有关。在这里，我们进行了一项基于坐标的荟萃分析，结合了 11 项 BOLD-fMRI 研究，比较了精神分裂症患者和健康对照之间的奖励预期信号。我们观察到在额叶-纹状体网络中精神分裂症患者的激活差异减少。元回归表明，这种功能特征与精神病症状的严重程度有关，并且即使在控制了抗精神病药物的剂量后仍然存在。