Background

Phenolic compounds have been studied for a variety number of bioactivities using in vitro, ex vivo, and in vivo protocols. Most of the studies dealing with phenolic compounds deal with in vitro antioxidant, antihypertensive, anti-inflammatory, antipyretic, antihemolytic effects in human erythrocytes, hypolipidemic, and antiproliferative activities.

Scope and approach

Companies have used the overall understanding of the beneficial effects of polyphenols to develop “functional” ingredients and foods. However, the main question that arises is still the target of warm discussions: Is the higher ingestion of phenolic compounds the best dietary strategy? Our commentary focuses on this question and we list some examples in which phenolic compounds show deleterious effects in vivo.

Key findings and conclusions

Two main conclusions arise: (i) any presumption of “functional effects” based on test-tube studies should be avoided as these results do not represent the real biological effect in humans; (ii) at high concentrations and in specific populations, polyphenols may have several potential adverse health effects presumably associated to their pro-oxidative capacity. All in one, the dietary supplementation containing high doses of polyphenols should be well justified in each case until a consensus is reached supported on medical, nutritional and toxicological data.

中文翻译：

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摄入更高的酚类化合物是最佳饮食策略吗？关于多酚在体内有害作用的科学见解

背景

已使用体外，离体和体内方案研究了酚类化合物的多种生物活性。有关酚类化合物的大多数研究涉及体外抗氧化，降压，抗炎，解热，抗溶血作用对人红细胞，降血脂和抗增殖活性。

范围和方法

公司利用对多酚的有益作用的整体理解来开发“功能性”成分和食品。但是，出现的主要问题仍然是热烈讨论的目标：摄入更多的酚类化合物是否是最佳的饮食策略？我们的评论集中在这个问题上，我们列举了酚类化合物在体内显示有害作用的一些例子。

主要发现和结论

得出两个主要结论：（i）应避免基于试管研究的任何“功能效应”推定，因为这些结果并不代表对人体的真正生物学效应；（ii）在高浓度和特定人群中，多酚可能具有几种潜在的不利健康影响，据推测可能与它们的抗氧化能力有关。总而言之，在每种情况下，都应充分证明含有高剂量多酚的膳食补充剂的合理性，直到在医学，营养和毒理学数据上达成共识为止。