Cells integrate intracellular and extracellular cues to precisely control the balance of anabolic and catabolic processes, which is essential for cells to maintain homeostasis. The nuclear protein TP53INP2 (tumor protein p53 inducible nuclear protein 2) has emerged as one of the key players participating in both anabolic and catabolic processes. In the nucleus including the nucleolus, TP53INP2 binds to multiple transcription-related factors to modulate transcription, such as the transcription of thyroid hormone-related genes and ribosomal DNA. Interestingly, upon nutrient deprivation, TP53INP2 rapidly moves from the nucleus to the cytoplasm and participates in the regulation of macroautophagy/autophagy. By acting as a nutrient status sensor, TP53INP2 switches its role between transcription and autophagy by changing its subcellular localization and helps the cell to cope with environmental changes.

Abbreviations

Atg: autophagy related; LIR: LC3-interacting region; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; MTORC1: mechanistic target of rapamycin kinase complex 1; rDNA: ribosomal DNA; TP53INP2: tumor protein p53 inducible nuclear protein 2; UIM: ubiquitin-interacting motif

中文翻译：

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TP53INP2 在转录和自噬中的双功能作用。

细胞整合细胞内和细胞外信号以精确控制合成代谢和分解代谢过程的平衡，这对于细胞维持体内平衡至关重要。核蛋白 TP53INP2（肿瘤蛋白 p53 诱导核蛋白 2）已成为参与合成代谢和分解代谢过程的关键参与者之一。在包括核仁在内的细胞核中，TP53INP2 与多个转录相关因子结合以调节转录，例如甲状腺激素相关基因和核糖体 DNA 的转录。有趣的是，在营养剥夺后，TP53INP2 迅速从细胞核移动到细胞质并参与巨自噬/自噬的调节。通过充当营养状态传感器，

缩写

Atg：自噬相关；LIR：LC3相互作用区；MAP1LC3/LC3：微管相关蛋白 1 轻链 3；MTORC1：雷帕霉素激酶复合物 1 的机械靶点；rDNA：核糖体DNA；TP53INP2：肿瘤蛋白p53诱导核蛋白2；UIM：泛素相互作用基序