Antihypertensive therapy and sudden cardiac death, should we expect the unexpected?,Journal of Human Hypertension

当前位置： X-MOL 学术 › J. Hum. Hypertens. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Antihypertensive therapy and sudden cardiac death, should we expect the unexpected?
Journal of Human Hypertension ( IF 2.7 ) Pub Date : 2020-01-14 , DOI: 10.1038/s41371-020-0299-3
Elias Sanidas ₁ , Konstantinos Malliaras ₁ , Dimitrios Papadopoulos ₁ , Maria Velliou ₁ , Konstantinos Tsakalis ₁ , Kanella Zerva ₁ , John Barbetseas ₁

Affiliation

Hypertension (HTN) and sudden cardiac death (SCD) constitute major public health problems accounting for millions of deaths each year worldwide. Both HTN and HTN-induced left ventricular hypertrophy (LVH) have been shown to be independent risk factors for SCD. However, the association between antihypertensive pharmacotherapy and risk of SCD has been under-investigated. Given that antihypertensive pharmacotherapy effectively reduces overall cardiovascular mortality, it would be expected to protect patients from SCD. Nevertheless, available data demonstrate that antihypertensive medications (primarily thiazide diuretics), while effective in reducing the incidence of myocardial infarction, do not confer protection from SCD. The purpose of this review was to present the relationship between HTN, LVH, and SCD and to describe the potential association between antihypertensive pharmacotherapy and risk of SCD.

中文翻译：

降压治疗和心源性猝死，我们应该期待意外吗？

高血压 (HTN) 和心源性猝死 (SCD) 构成了主要的公共卫生问题，每年导致全球数百万人死亡。HTN 和 HTN 诱导的左心室肥大 (LVH) 均已被证明是 SCD 的独立危险因素。然而，抗高血压药物治疗与 SCD 风险之间的关联尚未得到充分研究。鉴于抗高血压药物治疗可有效降低总体心血管死亡率，预计可保护患者免受 SCD 的侵害。然而，现有数据表明，抗高血压药物（主要是噻嗪类利尿剂）虽然能有效降低心肌梗塞的发生率，但不能对 SCD 产生保护作用。本综述的目的是介绍 HTN、LVH、

更新日期：2020-01-14

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11