Enhancement of glucose homeostasis through the PI3K/Akt signaling pathway by dietary with Agaricus blazei Murrill in STZ‐induced diabetic rats,Food Science & Nutrition

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Enhancement of glucose homeostasis through the PI3K/Akt signaling pathway by dietary with Agaricus blazei Murrill in STZ‐induced diabetic rats
Food Science & Nutrition ( IF 3.5 ) Pub Date : 2020-01-13 , DOI: 10.1002/fsn3.1397
Qi Wei ₁ , Jie Li ₁ , Yishu Zhan ₁ , Qiangui Zhong ₁ , Baogui Xie ₂ , Lei Chen ₁ , Bingzhi Chen ₁ , Yuji Jiang ₁

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Agaricus blazei Murrill (ABM) is an edible fungus. This study investigated the protective role of ABM fruiting body against streptozotocin (STZ)‐induced diabetic rats. After 4 weeks of ABM supplement, glucose homeostasis was improved in diabetic rats. Quantitative real‐time and Western blot analyses suggested that ABM could promote the gene and protein expression level of insulin receptor, pyruvate dehydrogenase kinase, phospho‐kinase B, kinase B, phosphatidylinositol 3‐kinase, insulin receptor substrate 1, glucose transporter‐4, and glutamine synthetase, while inhibiting the expression of glycogen synthase kinase 3β and c‐jun N‐terminal kinase 1 and 2. According to multivariate and univariate statistical analysis, liver metabolite profiles of the normal and diabetic rats fed basal and experimental diet were clearly separated. The differential liver metabolites from diabetic rats fed basal and ABM diet‐related pathways including the glycolysis pathway, pentose phosphate pathway, tricarboxylic acid cycle, and oxidative phosphorylation were analyzed. A total of 18 potential biomarker metabolites were identified as differential biomarkers associated with ABM supplement diet.

中文翻译：

姬松茸饮食通过 PI3K/Akt 信号通路增强 STZ 诱导的糖尿病大鼠的葡萄糖稳态

姬松茸(ABM) 是一种食用菌。本研究探讨了 ABM 子实体对链脲佐菌素 (STZ) 诱导的糖尿病大鼠的保护作用。补充 ABM 4 周后，糖尿病大鼠的葡萄糖稳态得到改善。实时定量和蛋白质印迹分析表明，ABM 可以促进胰岛素受体、丙酮酸脱氢酶激酶、磷酸激酶 B、激酶 B、磷脂酰肌醇 3 激酶、胰岛素受体底物 1、葡萄糖转运蛋白 4、和谷氨酰胺合成酶，同时抑制糖原合成酶激酶 3β 和 c-jun N 末端激酶 1 和 2 的表达。根据多变量和单变量统计分析，喂食基础饮食和实验饮食的正常和糖尿病大鼠的肝脏代谢谱明显分开。分析了基础饮食和 ABM 饮食相关途径（包括糖酵解途径、磷酸戊糖途径、三羧酸循环和氧化磷酸化）喂养的糖尿病大鼠的差异肝脏代谢物。总共 18 种潜在的生物标志物代谢物被鉴定为与 ABM 补充饮食相关的差异生物标志物。

更新日期：2020-01-13

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