Simultaneous edited MRS of GABA, glutathione, and ethanol.,NMR in Biomedicine

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Simultaneous edited MRS of GABA, glutathione, and ethanol.
NMR in Biomedicine ( IF 2.7 ) Pub Date : 2020-01-14 , DOI: 10.1002/nbm.4227
Muhammad G Saleh _{1,

2} , Min Wang _{1,

2} , Mark Mikkelsen _{1,

2} , Steve C N Hui _{1,

2} , Georg Oeltzschner _{1,

2} , Jeff Boissoneault _{3,

4,

5} , Bethany Stennett _{3,

4,

5} , Richard A E Edden _{1,

2} , Eric C Porges _{3,

6}

Affiliation

The aim of this work was to develop simultaneous edited MRS of γ-aminobutyric acid (GABA), glutathione (GSH), and ethanol (EtOH) using Hadamard encoding and reconstruction of MEGA-edited spectroscopy (HERMES) at 3T. Density-matrix simulations of HERMES were carried out and compared with phantom experiments. In vivo experiments were performed in six healthy volunteers about 30 min after alcohol consumption. Simulations of HERMES showed GABA-, GSH-, and EtOH-edited spectra with low levels of crosstalk and excellent agreement with phantom spectra. In vivo experiments showed well edited GABA signals at 3.0 ppm, GSH at 2.95 ppm, and EtOH at 1.18 ppm in the respective Hadamard combination spectra. Measured integral ratios were 0.082 ± 0.012 for GABA/Cr, 0.037 ± 0.006 for GSH/Cr, and 0.305 ± 0.129 for EtOH/Cr. Simulated, phantom, and in vivo measurements of HERMES show excellent separation of GABA-, GSH-, and EtOH-edited signals with negligible levels of crosstalk. HERMES allows a threefold acceleration of editing while maintaining spectral quality compared with sequentially acquired MEGA-PRESS measurements.

中文翻译：

同时编辑了GABA，谷胱甘肽和乙醇的MRS。

这项工作的目的是利用Hadamard编码和3T的MEGA编辑光谱法（HERMES）的重建，开发同时编辑的γ-氨基丁酸（GABA），谷胱甘肽（GSH）和乙醇（EtOH）的MRS。进行了HERMES的密度矩阵模拟，并与幻像实验进行了比较。饮酒约30分钟后，对六名健康志愿者进行了体内实验。HERMES的仿真显示GABA-，GSH-和EtOH编辑的光谱具有较低的串扰水平，并且与幻像光谱的一致性极佳。体内实验显示，在各自的Hadamard组合光谱中，编辑良好的GABA信号为3.0 ppm，GSH为2.95 ppm，EtOH为1.18 ppm。对于GABA / Cr，测得的积分比为0.082±0.012，对于GSH / Cr为0.037±0.006，对于EtOH / Cr为0.305±0.129。模拟，幻影，HERMES的体内测量结果表明，GABA，GSH和EtOH编辑的信号具有极好的分离效果，串扰水平可忽略不计。与顺序获取的MEGA-PRESS测量结果相比，HERMES可以在保持频谱质量的同时加快三倍的编辑速度。

更新日期：2020-03-09

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