Cover Feature: Proline Derived Bicyclic Derivatives through Metal Catalysed Cyclisations of Allenes: Synthesis of Longamide B, Stylisine D and their Derivatives (Eur. J. Org. Chem. /2020),European Journal of Organic Chemistry

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Cover Feature: Proline Derived Bicyclic Derivatives through Metal Catalysed Cyclisations of Allenes: Synthesis of Longamide B, Stylisine D and their Derivatives (Eur. J. Org. Chem. /2020)
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2020-01-14 , DOI: 10.1002/ejoc.202000038
Milos Jovanovic ₁ , Milos Petkovic ₁ , Predrag Jovanovic ₁ , Milena Simic ₁ , Gordana Tasic ₁ , Slavica Eric ₂ , Vladimir Savic ₁

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The Cover Feature shows a synthesis of bromopyrrole alkaloids produced by marine sponges. While the silver‐catalysed route provides access to naturally occurring Longamide B and Stylisine D, the palladium route enables synthesis of analogues of these molecules. An intermediate involved in the key cyclisation step that bridges these methods is a proline derived allene. Details are discussed in the article by M. Jovanovic et al. We thank IRD / Philippe Borsa for kindly allowing us to use his original photo of the sponge Stylissa massa, a natural producer of Stylisine D. More information can be found in the Full Paper by M. Petkovic, V. Savic et al.

中文翻译：

封面人物：丙二烯的金属催化环化衍生脯氨酸衍生的双环衍生物：长酰胺B，苯乙烯基丁二烯D及其衍生物的合成（Eur。J. Org。Chem。/ 2020）

封面特征显示了由海洋海绵生产的溴吡咯生物碱的合成。尽管银催化的途径提供了与天然存在的长酰胺B和苯乙烯基丁酯D的接触途径，但钯途径却可以合成这些分子的类似物。桥接这些方法的关键环化步骤涉及的中间体是脯氨酸衍生的异戊烯。M. Jovanovic等人的文章中讨论了详细信息。感谢IRD / Philippe Borsa的慷慨允许我们使用他的海绵Stylissa massa的原始照片，该海绵是Stylisine D的天然生产者。

更新日期：2020-01-14

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