T-regulatory cells (Tregs) represent a unique subpopulation of helper T-cells by maintaining immune equilibrium using various mechanisms. The role of T-cell receptors (TCR) in providing homeostasis and activation of conventional T-cells is well-known; however, for Tregs, this area is understudied. In the last two decades, evidence has accumulated to confirm the importance of the TCR in Treg homeostasis and antigen-specific immune response regulation. In this review, we describe the current view of Treg subset heterogeneity, homeostasis and function in the context of TCR involvement. Recent studies of the TCR repertoire of Tregs, combined with single-cell gene expression analysis, revealed the importance of TCR specificity in shaping Treg phenotype diversity, their functions and homeostatic maintenance in various tissues. We propose that Tregs, like conventional T-helper cells, act to a great extent in an antigen-specific manner, which is provided by a specific distribution of Tregs in niches.

中文翻译：

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Treg异质性，功能和体内平衡。

T调节细胞（Tregs）通过使用各种机制维持免疫平衡来代表辅助性T细胞的独特亚群。T细胞受体（TCR）在提供稳态和常规T细胞活化方面的作用是众所周知的；但是，对于Tregs，该领域的研究不足。在过去的二十年中，已经积累了证据来证实TCR在Treg稳态和抗原特异性免疫应答调节中的重要性。在这篇综述中，我们描述了在TCR参与的背景下Treg子集异质性，体内稳态和功能的当前观点。Tregs的TCR库的最新研究与单细胞基因表达分析相结合，揭示了TCR特异性在塑造Treg表型多样性，其功能以及在各种组织中保持体内平衡的重要性。我们建议Tregs