PURPOSE Little is known about health-related quality of life (HRQoL) in patients with chronic hepatitis B virus (CHB) infection in the United States. Our goal is to understand factors associated with HRQoL in this population. METHODS We conducted a survey to assess HRQoL and behavioral risks among patients with CHB infection from four large U.S. health care systems. Primary outcomes were generated from the SF-8 scale to assess HRQoL, as measured by the mental component scores (MCS) and physical component scores (PCS). The survey also measured socio-demographic information, hepatitis-related behavioral risk factors, treatment exposure/history, stress, and social support. We supplemented survey data with electronic health records data on patient income, insurance, disease severity, and comorbidities. Multivariate analysis was used to estimate and compare adjusted least square means of MCS and PCS, and examine which risk factors were associated with lower MCS and PCS. RESULTS Nine hundred sixty-nine patients (44.6%) responded to the survey. Current life stressors and unemployment were associated with both lower MCS and PCS results in multivariate analyses. Lower MCS was also associated with White race and low social support, while lower PCS was also associated with Medicaid insurance. CONCLUSIONS Stressful life events and unemployment were related to mental and physical health status of CHB patients. Those who have social support have better mental health; White and Medicaid patients are more likely to have poorer mental and physical health, respectively. Management of CHB patients should include stress management, social support, and financial or employment assistance.

中文翻译：

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慢性乙型肝炎患者的心理和身体健康状况。

目的在美国，关于慢性乙型肝炎病毒（CHB）感染患者的健康相关生活质量（HRQoL）知之甚少。我们的目标是了解此人群中与HRQoL相关的因素。方法我们进行了一项调查，以评估来自美国四个大型卫生保健系统的CHB感染患者的HRQoL和行为风险。主要结局由SF-8量表产生，以评估HRQoL，通过心理成分评分（MCS）和身体成分评分（PCS）进行衡量。该调查还测量了社会人口统计学信息，与肝炎相关的行为危险因素，治疗暴露/历史，压力和社会支持。我们用有关患者收入，保险，疾病严重程度和合并症的电子健康记录数据来补充调查数据。使用多变量分析来估计和比较经调整的MCS和PCS的最小二乘均值，并检查哪些风险因素与较低的MCS和PCS相关。结果969名患者（44.6％）回答了调查。在多变量分析中，当前生活压力源和失业与较低的MCS和PCS结果相关。较低的MCS也与白人种族和社会支持低有关，而较低的PCS也与医疗补助保险有关。结论紧张的生活事件和失业与CHB患者的心理和身体健康状况有关。有社会支持的人的心理健康更好；白人和医疗补助患者的心理和身体健康状况较差。CHB患者的管理应包括压力管理，社会支持，