PURPOSE To examine the prospective associations between body mass index (BMI) and health-related quality of life (HRQoL). METHODS Data were extracted from a longitudinal, nationally representative sample of 9916 men and women aged 18 years and over who were followed annually between 2006 and 2016 in the Household, Income and Labour Dynamics in Australia (HILDA) survey. HRQoL was assessed using the self-administered SF-36 questionnaire annually between 2006 (baseline) and 2016. BMI was calculated from self-reported height and weight and was classified into the following four categories of baseline BMI: underweight (< 18.5 kg/m2), normal weight (18.5-24.9 kg/m2), overweight (25-29.9 kg/m2) and obese (≥ 30 kg/m2). We used linear mixed-effects regression models to investigate the associations between change in BMI (kg/m2) and concurrent changes in HRQoL scores over 11 years. RESULTS BMI gain was associated with deterioration of Physical Component Summary (PCS) (P < 0.001), but not with change in Mental component summary (MCS) over the 11-year period. BMI gain was inversely associated (P < 0.001) with five of the eight HRQoL domains (physical functioning, role physical, bodily pain, general health and vitality) with a significant graded association according to baseline BMI category. Over the 11-year study period, every unit increase in PCS was associated with a decrease of 0.02 (P < 0.001), 0.03 (P < 0.001) and 0.04 (P < 0.001) BMI units per year among participants who were normal, overweight and obese at baseline, respectively. Five of the eight domains of HRQoL (physical functioning, role physical, bodily pain, general health and vitality) were inversely associated with BMI (P < 0.001) with a significant graded association according to baseline BMI category. CONCLUSIONS Weight gain was not only associated with deterioration of HRQoL, and vice versa. The bi-directional association was stronger for physical than mental domains of HRQoL.

中文翻译：

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体重变化与健康相关的生活质量之间存在双向关联：来自9916位社区居民成年人11年随访的证据。

目的研究体重指数（BMI）与健康相关的生活质量（HRQoL）之间的前瞻性关联。方法数据是从9916名18岁及以上的男性和女性的纵向全国代表性样本中提取的，这些样本在2006年至2016年期间每年接受《澳大利亚家庭，收入和劳动动力》（HILDA）调查。在2006年（基线）至2016年之间，每年使用自我管理的SF-36问卷对HRQoL进行评估。BMI是根据自我报告的身高和体重计算得出的，分为以下四类基线BMI：体重不足（<18.5 kg / m2 ），正常体重（18.5-24.9 kg / m2），超重（25-29.9 kg / m2）和肥胖（≥30 kg / m2）。我们使用线性混合效应回归模型来调查11年来BMI（kg / m2）的变化与HRQoL分数的同时变化之间的关联。结果BMI的增加与身体成分摘要（PCS）的恶化有关（P <0.001），但与11年期间精神成分摘要（MCS）的变化无关。根据基线BMI类别，BMI增益与八个HRQoL域（身体功能，身体角色，身体疼痛，总体健康和活力）中的五个反向关联（P <0.001），且具有显着的分级关联。在为期11年的研究期内，正常，超重的参与者中，PCS的每增加一单位，每年BMI单位分别减少0.02（P <0.001），0.03（P <0.001）和0.04（P <0.001）BMI单位。和肥胖分别在基线。HRQoL的八个领域中的五个（身体机能，身体角色，身体疼痛，总体健康和活力）与BMI呈负相关（P <0.001），并且根据基线BMI类别具有显着的分级关联。结论体重增加不仅与HRQoL降低有关，反之亦然。HRQoL的物理领域比精神领域的双向关联更强。