The mapping of diattenuation, polarizance and retardance vector (normalized Stokes vector) on Poincare sphere, evaluated from Mueller matrix of optically anisotropic stromal region of cervical tissues, is presented for cervical precancer detection and its staging. This reveals that the changes in the polarization states shown by these normalized Stokes vectors corresponds to the degradation of linearly arranged collagen fibers, breakage of the collagen cross links in the stromal region and change in the density of scattering sites when cervical cancer evolves. The distinct nature of real and imaginary parts of the refractive index for linear, linear‐45 and circular polarization from the optically anisotropic stromal region underscore the various polarization structures of the connective tissue region which get modified during the pathological changes. It has been found that versatility of these vectors for normal and precancerous cervical tissue of various grades may be utilized as a key distinction for qualitative staging of cervical precancer tissue. Quantitative classification of precancerous stages of cervical precancer has been determined with 95%–100% sensitivity and 93%–100% specificity through the evaluation of linear and circular diattenuation, linear polarizance and linear birefringence from the components of the respective vectors.

中文翻译：

---

庞加莱球上的延迟，扩散和极化矢量的映射，用于宫颈癌的诊断和分类。

根据宫颈组织的光学各向异性基质区域的Mueller矩阵，对Poincare球上的衰减，极化和延迟矢量（归一化的Stokes矢量）进行了映射，用于宫颈癌前期检测及其分期。这表明，当宫颈癌发展时，这些归一化的斯托克斯矢量所显示的极化状态的变化对应于线性排列的胶原纤维的降解，基质区域中胶原交联的断裂以及散射位点密度的变化。线性的折射率的实部和虚部具有不同的性质，光学各向异性基质区域的线性-45和圆偏振强调了结缔组织区域的各种偏振结构，这些结构在病理变化过程中发生了改变。已经发现这些载体对于各种等级的正常和癌前宫颈组织的通用性可以用作对宫颈癌前组织进行定性分期的关键区别。通过评估各个载体成分的线性和圆形衰减，线性极化率和线性双折射，已确定宫颈癌前期癌的定量分类具有95％–100％的敏感性和93％–100％的特异性。已经发现这些载体对于各种等级的正常和癌前宫颈组织的通用性可以用作对宫颈癌前组织进行定性分期的关键区别。通过评估各个载体成分的线性和圆形衰减，线性极化率和线性双折射，已确定宫颈癌前期癌的定量分类具有95％–100％的敏感性和93％–100％的特异性。已经发现这些载体对于各种等级的正常和癌前宫颈组织的通用性可以用作对宫颈癌前组织进行定性分期的关键区别。通过评估各个载体成分的线性和圆形衰减，线性极化率和线性双折射，已确定宫颈癌前期癌的定量分类具有95％–100％的敏感性和93％–100％的特异性。