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Decomposition of amyloid fibrils by NIR-active upconversion nanoparticles.
Photochemical & Photobiological Sciences ( IF 2.7 ) Pub Date : 2020-01-14 , DOI: 10.1039/c9pp00356h
Takunori Harada 1 , Hiraku Matsuzaki 1 , Ryohei Oyama 1 , Takuma Takeuchi 1 , Tomoaki Takei 1 , Taisuke Ninomiya 1 , Kouta Takami 1 , Takanori Inoue 1 , Hiroyasu Nishiguchi 2 , Emi Hifumi 2 , Hiroyuki Shinto 3 , Hiromi Takahashi 4 , Kazuo Umemura 5
Affiliation  

We demonstrate amyloid fibril (AF) decomposition induced by NIR-active upconversion nanoparticles complexed with photosensitisers. The process is triggered by upconversion, which initiates a photochemical reaction cascade that culminates in the generation of the highly reactive singlet-oxygen product 1O2 close to the amyloid superstructures, resulting in AF decomposition.

中文翻译:

NIR活性上转换纳米粒子分解淀粉样蛋白原纤维。

我们证明了与光敏剂复合的近红外活性上转换纳米颗粒诱导的淀粉样原纤维(AF)分解。该过程由上转换触发,上转换引发光化学反应级联,最终导致在接近淀粉样超结构的高反应性单线态氧产物1O2的生成中导致AF分解。
更新日期:2020-02-13
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