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Dendritic silica with carbon dots and gold nanoclusters for dual nanozymes
New Journal of Chemistry ( IF 2.7 ) Pub Date : 2020/01/14 , DOI: 10.1039/c9nj05655f
Lirong Zhao 1, 2, 3, 4, 5 , Xiangling Ren 1, 2, 3, 4, 5 , Jing Zhang 1, 2, 3, 4, 5 , Wei Zhang 6, 7, 8, 9, 10 , Xudong Chen 6, 7, 8, 9, 10 , Xianwei Meng 1, 2, 3, 4, 5
Affiliation  

Many biochemical processes are accomplished by multiple enzymes, so it is important to develop nanocomposite microspheres with multiple enzyme mimetic ability. Here, well-designed nanozyme engineering (termed dSCS-Au NPs) was established for dual nanozymes with dendritic silica spheres (dSs) used as a carrier. The carbon dots (C-dots) were covalently immobilized into the interior surface of amino-terminated dSs, while gold nanoclusters (Au NCs) were linked to the surface of the dSs through activating agents of EDC/NHS. The dSCS-Au NPs exhibited excellent compatibility for two nanozymes, maintaining the superoxide dismutase (SOD)-like activity of C-dots and improving the horseradish peroxidase (HRP)-like activity of Au NCs. In addition, the HRP-like activity of dSCS-Au NPs could be regulated by changing the amount of loading of Au NCs. It has promising applications in biocatalysis with multiple enzyme reactions in the future.

中文翻译:

具有碳点和金纳米簇的树枝状二氧化硅,用于双重纳米酶

许多生化过程是由多种酶完成的,因此开发具有多种酶模拟能力的纳米复合微球非常重要。在这里,建立了设计良好的纳米酶工程学(称为dSCS-Au NPs),用于以树枝状二氧化硅球(dSs)为载体的双重纳米酶。碳点(C点)被共价固定在氨基末端dSs的内表面,而金纳米团簇(Au NCs)通过EDC / NHS的活化剂连接到dSs的表面。dSCS-Au NP对两种纳米酶表现出优异的相容性,保持了C点的超氧化物歧化酶(SOD)样活性,并改善了Au NCs的辣根过氧化物酶(HRP)活性。此外,dSCS-Au NPs的HRP样活性可以通过改变Au NCs的负载量来调节。
更新日期:2020-02-10
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