Dendritic silica with carbon dots and gold nanoclusters for dual nanozymes,New Journal of Chemistry

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Dendritic silica with carbon dots and gold nanoclusters for dual nanozymes
New Journal of Chemistry ( IF 2.7 ) Pub Date : 2020/01/14 , DOI: 10.1039/c9nj05655f
Lirong Zhao _{1,

2,

3,

4,

5} , Xiangling Ren _{1,

2,

3,

4,

5} , Jing Zhang _{1,

2,

3,

4,

5} , Wei Zhang _{6,

7,

8,

9,

10} , Xudong Chen _{6,

7,

8,

9,

10} , Xianwei Meng _{1,

2,

3,

4,

5}

Affiliation

Many biochemical processes are accomplished by multiple enzymes, so it is important to develop nanocomposite microspheres with multiple enzyme mimetic ability. Here, well-designed nanozyme engineering (termed dSCS-Au NPs) was established for dual nanozymes with dendritic silica spheres (dSs) used as a carrier. The carbon dots (C-dots) were covalently immobilized into the interior surface of amino-terminated dSs, while gold nanoclusters (Au NCs) were linked to the surface of the dSs through activating agents of EDC/NHS. The dSCS-Au NPs exhibited excellent compatibility for two nanozymes, maintaining the superoxide dismutase (SOD)-like activity of C-dots and improving the horseradish peroxidase (HRP)-like activity of Au NCs. In addition, the HRP-like activity of dSCS-Au NPs could be regulated by changing the amount of loading of Au NCs. It has promising applications in biocatalysis with multiple enzyme reactions in the future.

中文翻译：

具有碳点和金纳米簇的树枝状二氧化硅，用于双重纳米酶

许多生化过程是由多种酶完成的，因此开发具有多种酶模拟能力的纳米复合微球非常重要。在这里，建立了设计良好的纳米酶工程学（称为dSCS-Au NPs），用于以树枝状二氧化硅球（dSs）为载体的双重纳米酶。碳点（C点）被共价固定在氨基末端dSs的内表面，而金纳米团簇（Au NCs）通过EDC / NHS的活化剂连接到dSs的表面。dSCS-Au NP对两种纳米酶表现出优异的相容性，保持了C点的超氧化物歧化酶（SOD）样活性，并改善了Au NCs的辣根过氧化物酶（HRP）活性。此外，dSCS-Au NPs的HRP样活性可以通过改变Au NCs的负载量来调节。

更新日期：2020-02-10

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