Heteromolecular compounds in binary systems of amino acids with opposite and same chiralities,CrystEngComm

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Heteromolecular compounds in binary systems of amino acids with opposite and same chiralities
CrystEngComm ( IF 2.6 ) Pub Date : 2020/01/14 , DOI: 10.1039/c9ce01333d
Anton I. Isakov _{1,

2,

3,

4} , Heike Lorenz _{5,

6,

7} , Andrey A. Zolotarev _{1,

2,

3,

4} , Elena N. Kotelnikova _{1,

2,

3,

4}

Affiliation

A classification of discrete compounds in binary chiral systems of single and different substances (homo- and heteromolecular compounds) is presented. It considers both chemical and crystallographic characteristics of such compounds. Using amino acids as chiral model systems, features of crystal structures of equimolar and non-equimolar heteromolecular compounds are reviewed. In this connection, the concept of homo- and heteromolecular dimers in compounds formed by amino acids is introduced and analyzed. As a result, a correlation between the molecular dimer type and the side chain structure (linear or branched) and the conformation (extended or folded) of the relevant compounds' molecules is derived. Two non-equimolar discrete heterocompounds discovered in the chiral systems L-valine–L-isoleucine and L-valine–L-leucine are discussed using the concepts proposed. The previously studied first system features a 2 : 1 (Val : Ile) compound. A newly investigated second system is found to form a 3 : 1 (Val : Leu) compound, and its crystal structure is described and evaluated.

中文翻译：

具有相反和相同手性的氨基酸二元体系中的杂分子化合物

介绍了单一和不同物质（均分子和异分子化合物）的二元手性体系中离散化合物的分类。它考虑了这类化合物的化学和晶体学特征。使用氨基酸作为手性模型系统，审查了等摩尔和非等摩尔异分子化合物的晶体结构特征。关于这一点，引入并分析了由氨基酸形成的化合物中的同分子和异分子二聚体的概念。结果，推导了分子二聚体类型与侧链结构（直链或支链）与相关化合物分子的构象（延伸或折叠）之间的相关性。在手性系统L-缬氨酸– L中发现了两个非等量的离散杂化合物-异亮氨酸和L-缬氨酸-L-亮氨酸使用提出的概念进行了讨论。先前研究的第一个系统具有2：1（Val：Ile）化合物的特征。发现新研究的第二系统形成3：1（Val：Leu）化合物，并描述和评估其晶体结构。

更新日期：2020-02-13

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