当前位置：
X-MOL 学术
›
Dalton Trans.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Lanthanide conjugates as versatile instruments for therapy and diagnostics
Dalton Transactions ( IF 3.5 ) Pub Date : 2020/01/14 , DOI: 10.1039/c9dt04851k Claudine Herlan 1, 2, 3, 4 , Stefan Bräse 1, 2, 3, 4, 5
Dalton Transactions ( IF 3.5 ) Pub Date : 2020/01/14 , DOI: 10.1039/c9dt04851k Claudine Herlan 1, 2, 3, 4 , Stefan Bräse 1, 2, 3, 4, 5
Affiliation
|
Lanthanides have demonstrated outstanding properties in many fields of research including biology and medicinal chemistry. Their unique luminescence and magnetic properties make them the metals of choice for next generation theranostics that efficiently combine the two central pillars of medicine – diagnostics and therapy. Attached to targeting units, lanthanide complexes pave the way for real-time imaging of drug uptake and distribution as well as specific regulation of subcellular processes with few side effects. This enables individualized treatment options for severe diseases characterized by altered cell expression. The highly diverse results achieved as well as insights into the challenges that research in this area has to face in the upcoming years will be summarized in the present review.
中文翻译：
镧系元素偶联物可作为多功能仪器进行治疗和诊断
镧系元素已在包括生物学和药物化学在内的许多研究领域中表现出出色的性能。它们独特的发光和磁性质使其成为下一代诊断学的首选金属，它们有效地结合了医学的两个中心支柱-诊断和治疗。镧系元素复合物与靶向单元相连，为药物摄取和分布的实时成像以及对亚细胞过程的特定调节产生很少的副作用铺平了道路。这为以细胞表达改变为特征的严重疾病提供了个性化的治疗选择。本综述总结了所取得的高度多样化的结果以及对未来几年该领域研究必须面对的挑战的见识。
更新日期：2020-02-26
中文翻译：
镧系元素偶联物可作为多功能仪器进行治疗和诊断
镧系元素已在包括生物学和药物化学在内的许多研究领域中表现出出色的性能。它们独特的发光和磁性质使其成为下一代诊断学的首选金属，它们有效地结合了医学的两个中心支柱-诊断和治疗。镧系元素复合物与靶向单元相连，为药物摄取和分布的实时成像以及对亚细胞过程的特定调节产生很少的副作用铺平了道路。这为以细胞表达改变为特征的严重疾病提供了个性化的治疗选择。本综述总结了所取得的高度多样化的结果以及对未来几年该领域研究必须面对的挑战的见识。
京公网安备 11010802027423号