BACKGROUND Congenital limb malformations are rare, and their perinatal outcomes are not well described. This study analyzed the perinatal outcomes of infants with congenital limb malformations. METHODS All infants with congenital limb malformations who underwent prenatal assessment and delivery at our tertiary referral center from 2004 through 2017 were retrospectively identified. Neonatal outcome parameters were assessed, and the predictors of worse perinatal outcomes were determined. RESULTS One hundred twenty-four cases of congenital limb malformations were identified, of which 104 (83.9%) were analyzed. The upper limb was affected in 15 patients (14.4%), the lower limb in 49 (47.1%), and both limbs in 40 (38.5%) patients. A fetal syndrome was identified in 66 patients (63.5%); clubfoot and longitudinal reduction defects were the most frequent malformations. In total, 38 patients (36.5%) underwent termination, seven (6.7%) had stillbirth, and 59 (56.7%) had live-born delivery. Rates of preterm delivery and transfer to the Neonatal Intensive Care Unit were 42.4 and 25.4%, respectively. Localization of the malformation was a determinant of perinatal outcome (P = .006) and preterm delivery (P = .046). CONCLUSIONS Congenital limb malformations frequently occur bilaterally and are associated with poor perinatal outcomes, including high rates of stillbirth and preterm delivery. Multidisciplinary care and referral to a perinatal center are warranted.

中文翻译：

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先天性肢体畸形婴儿的围产期结局：来自中欧三级转诊中心的一项观察性研究。

背景技术先天性肢体畸形很少见，其围产期结局也未得到很好的描述。这项研究分析了先天性肢体畸形婴儿的围产期结局。方法回顾性分析2004年至2017年间在我们的三级转诊中心接受产前评估和分娩的所有先天性肢体畸形婴儿。评估新生儿结局参数，并确定围产期结局恶化的预测因素。结果共发现124例先天性肢体畸形，其中104例（83.9％）被分析。上肢受累15例（14.4％），下肢受累49（47.1％），双肢受累40（38.5％）。在66名患者中发现了胎儿综合征（63.5％）；马蹄足和纵向复位缺陷是最常见的畸形。共有38例患者（36.5％）进行了终止治疗，其中7例（6.7％）进行了死产，59例（56.7％）进行了活产分娩。早产和新生儿重症监护病房的转移率分别为42.4％和25.4％。畸形的局限性是围产期结局（P = .006）和早产（P = .046）的决定因素。结论先天性肢体畸形经常在双侧发生，并与不良的围产期结局有关，包括高死产率和早产。必须进行多学科护理并转诊至围产中心。早产和新生儿重症监护病房的转移率分别为42.4％和25.4％。畸形的局限性是围产期结局（P = .006）和早产（P = .046）的决定因素。结论先天性肢体畸形经常在双侧发生，并与不良的围产期结局有关，包括高死产率和早产。必须进行多学科护理并转诊至围产中心。早产和新生儿重症监护病房的转移率分别为42.4％和25.4％。畸形的局限性是围产期结局（P = .006）和早产（P = .046）的决定因素。结论先天性肢体畸形经常在双侧发生，并与不良的围产期结局有关，包括高死产率和早产。必须进行多学科护理并转诊至围产中心。