Background Unsafe medication practices are the leading causes of avoidable patient harm in healthcare systems across the world. The largest proportion of which occurs during medication administration. Nurses play a significant role in the occurrence as well as preventions of medication administration errors. However, only a few relevant studies explored the problem in Ethiopia. Therefore, this study aimed to assess the magnitude and contributing factors of medication administration error among nurses in tertiary care hospitals, Addis Ababa, Ethiopia, 2018. Methods We conducted a hospital-based, cross-sectional study in Addis Ababa, Ethiopia. The study involved 298 randomly selected nurses. We used adopted, self-administered survey questionnaire and checklist to collect data via self-reporting and direct observation of nurses while administering medications. The tools were expert reviewed and tested on 5% of the study participants. We analyzed the data descriptively and analytically using SPSS version 24. We included those factors with significant p-values (p ≤ 0.25) in the multivariate logistic regression model. We considered those factors, in the final multivariate model, with p < 0.05 at 95%Cl as significant predictors of medication administration errors as defined by nurse self-report. Result Two hundred and ninety eight (98.3%) nurses completed the survey questionnaire. Of these, 203 (68.1%) reported committing medication administration errors in the previous 12 months. Factors such as the lack of adequate training [AOR = 3.16; 95% CI (1.67,6)], unavailability of a guideline for medication administration [AOR = 2.07; 95% CI (1.06,4.06)], inadequate work experience [AOR = 6.48; 95% CI (1.32,31.78)], interruption during medication administration [AOR = 2.42, 95% CI (1.3,4.49)] and night duty shift [AOR = 5, 95% CI (1.82, 13.78)] were significant predictors of medication administration errors at p-value < 0.05. Conclusion and recommendation Medication administration error prevention is complex but critical to ensure the safety of patients. Based on our study, providing a continuous training on safe administration of medications, making a medication administration guideline available for nurses to apply, creating an enabling environment for nurses to safely administer medications, and retaining more experienced nurses may be critical steps to improve the quality and safety of medication administration.

中文翻译：

---

护士用药错误和影响因素：埃塞俄比亚亚的斯亚贝巴三级医院的横断面研究。

背景 不安全的用药做法是全球医疗保健系统中可避免的患者伤害的主要原因。其中最大比例发生在用药期间。护士在用药错误的发生和预防中发挥着重要作用。然而，只有少数相关研究探讨了埃塞俄比亚的问题。因此，本研究旨在评估 2018 年埃塞俄比亚亚的斯亚贝巴三级护理医院护士用药错误的幅度和影响因素。方法我们在埃塞俄比亚亚的斯亚贝巴进行了一项以医院为基础的横断面研究。该研究涉及 298 名随机选择的护士。我们采用采用，自我管理的调查问卷和清单，通过自我报告和护士在给药时的直接观察来收集数据。这些工具经过专家审查，并在 5% 的研究参与者身上进行了测试。我们使用 SPSS 24 版对数据进行了描述性和分析性分析。我们将那些具有显着 p 值 (p ≤ 0.25) 的因素纳入了多元逻辑回归模型。我们在最终的多变量模型中考虑了这些因素，95%Cl 时 p < 0.05 作为护士自我报告定义的药物管理错误的重要预测因子。结果 298名护士（98.3%）完成了调查问卷。其中，203 人（68.1%）报告在过去 12 个月内犯了用药错误。缺乏足够培训等因素[AOR = 3.16; 95% 置信区间 (1.67, 6)]，药物管理指南不可用 [AOR = 2.07; 95% CI (1.06,4.06)]，工作经验不足 [AOR = 6.48; 95% CI (1.32,31.78)]、用药期间中断 [AOR = 2.42, 95% CI (1.3,4.49)] 和夜班 [AOR = 5, 95% CI (1.82, 13.78)] 是p 值 < 0.05 时的用药错误。结论与建议 预防用药错误是复杂的，但对于确保患者的安全至关重要。根据我们的研究，提供有关安全用药的持续培训，制定供护士应用的用药指南，为护士安全用药创造有利环境，