BACKGROUND Geriatric patients are at high risk of Drug Related Problems (DRPs) due to multi- morbidity associated polypharmacy, age related physiologic changes, pharmacokinetic and pharmacodynamics alterations. These patients often excluded from premarketing trials that can further increase the occurrence of DRPs. This study aimed to identify drug related problems and determinants in geriatric patients admitted to medical and surgical wards, and to evaluate the impact of clinical pharmacist interventions for treatment optimization. METHODS A prospective interventional study was conducted among geriatric patients admitted to medical and surgical wards of Jimma University Medical Center from April to July 2017. Clinical pharmacists reviewed patients drug therapy, identified drug related problems and provided interventions. Data were analyzed by using SPSS statistical software version 20.0. Descriptive statistics were performed to determine the proportion of drug related problems. Logistic regression analyses were performed to identify the determinants of drug related problems. RESULTS A total of 200 geriatric patients were included in the study. The mean age of the participants was 67.3 years (SD7.3). About 82% of the patients had at least one drug related problems. A total of 380 drug related problems were identified and 670 interventions were provided. For the clinical pharmacist interventions, the prescriber acceptance rate was 91.7%. Significant determinants for drug related problems were polypharmacy (adjusted odds ratio [AOR] = 4.350, 95% C.I: 1.212-9.260, p = 0.020) and number of comorbidities (AOR = 1.588, 95% C.I: 1.029-2.450, p = 0.037). CONCLUSIONS Drug related problems were substantially high among geriatric inpatients. Patients with polypharmacy and co-morbidities had a much higher chance of developing DRPs. Hence, special attention is needed to prevent the occurrence of DRPs in these patients. Moreover, clinical pharmacists' intervention was found to reduce DRPs in geriatric inpatients. The prescriber acceptance rate of clinical pharmacists' intervention was also substantially high.

中文翻译：

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老年患者的药物相关问题：临床药剂师干预的影响。

背景技术由于多发病相关的多药，年龄相关的生理变化，药代动力学和药效学改变，老年患者处于药物相关问题（DRP）的高风险中。这些患者通常被排除在上市前试验之外，这可以进一步增加DRP的发生。这项研究旨在确定收治内科和外科病房的老年患者的药物相关问题和决定因素，并评估临床药剂师干预措施对治疗优化的影响。方法2017年4月至2017年7月，对吉马大学医学中心内科和外科病房收治的老年患者进行了前瞻性干预研究。临床药剂师对患者的药物治疗进行了审查，确定了与药物有关的问题并提供了干预措施。使用SPSS统计软件20.0版分析数据。进行描述性统计以确定药物相关问题的比例。进行逻辑回归分析以确定与药物有关的问题的决定因素。结果总共有200名老年患者被纳入研究。参与者的平均年龄为67.3岁（SD7.3）。约82％的患者至少有一种与药物有关的问题。总共发现了380个与毒品有关的问题，并提供了670个干预措施。对于临床药剂师干预，开药者的接受率为91.7％。药物相关问题的重要决定因素是综合药店（调整后的优势比[AOR] = 4.350，95％CI：1.212-9.260，p = 0.020）和合并症的数量（AOR = 1.588，95％CI：1.029-2.450，p = 0.037） ）。结论在老年住院患者中，与药物有关的问题相当多。患有多种药物和合并症的患者发生DRP的机会更高。因此，需要特别注意防止在这些患者中发生DRP。此外，发现临床药剂师的干预可以减少老年患者的DRPs。临床药剂师干预的处方者接受率也很高。