In this study, platinum electrodes were fabricated on the bio-based poly(ethylene terephthalate) (Bio-PET) substrates for the development of flexible electrochemical sensors for the detection of Parkinson's disease biomarkers. Dopamine was detected by voltammetric measurements, displaying a 3.5 × 10-5 mol L-1 to 8.0 × 10-4 mol L-1 linear range with a limit of detection of 5.1 × 10-6 mol L-1. Parkinson's disease protein 7 (PARK7/DJ-1) was successfully detected by electrochemical impedance spectroscopy after electrode functionalization with specific anti-PARK7/DJ-1 antibodies. In this case, analytical curves presented a linear behavior from 40 ng mL-1 to 150 ng mL-1 of PARK7/DJ-1 with a limit of detection of 7.5 ng mL-1. Besides, the electrodes did not suffer any change in the electrochemical response after manual tests of mechanical tension. The proposed sensor and immunosensor were applied for the determination of Parkinson's disease biomarkers concentrations found in the human body, being adequate as an alternative method to diagnose this disease.

中文翻译：

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柔性铂电极可作为帕金森氏病生物标记物的电化学传感器和免疫传感器。

在这项研究中，铂电极是在生物基聚对苯二甲酸乙二醇酯（Bio-PET）基底上制造的，用于开发用于检测帕金森氏病生物标志物的柔性电化学传感器。通过伏安法检测多巴胺，显示出3.5×10-5 mol L-1至8.0×10-4 mol L-1的线性范围，检出限为5.1×10-6 mol L-1。在使用特定的抗PARK7 / DJ-1抗体对电极进行功能化后，通过电化学阻抗光谱法成功检测出帕金森氏病蛋白7（PARK7 / DJ-1）。在这种情况下，分析曲线显示了从40 ng mL-1到150 ng mL-1的PARK7 / DJ-1的线性行为，检出限为7.5 ng mL-1。此外，在手动测试机械张力后，电极的电化学响应没有任何变化。