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Acute Stroke During Pregnancy and Puerperium
Journal of the American College of Cardiology ( IF 21.7 ) Pub Date : 2020-01-01 , DOI: 10.1016/j.jacc.2019.10.056
Islam Y Elgendy 1 , Mohamed M Gad 2 , Ahmed N Mahmoud 3 , Ellen C Keeley 4 , Carl J Pepine 4
Affiliation  

BACKGROUND Acute stroke during pregnancy or within 6 weeks of childbirth is devastating for the mother and her family, yet data regarding incidence and contemporary trends are very limited. OBJECTIVES This study sought to investigate the incidence and outcomes of acute stroke and transient ischemic attack during pregnancy or within 6 weeks of childbirth in a large database. METHODS The National Inpatient Sample was queried to identify women age ≥18 years in the United States with pregnancy-related hospitalizations from January 1, 2007, to September 30, 2015. Temporal trends in acute stroke (ischemic and hemorrhagic)/transient ischemic attack incidence and in-hospital mortality were extracted. RESULTS Among 37,360,772 pregnancy-related hospitalizations, 16,694 (0.045%) women had an acute stroke. The rates of acute stroke did not change (42.8 per 100,000 hospitalizations in 2007 vs. 42.2 per 100,000 hospitalizations in 2015; ptrends = 0.10). Among those with acute stroke, there were increases in prevalence of obesity, smoking, hyperlipidemia, migraine, and gestational hypertension. Importantly, in-hospital mortality rates were almost 385-fold higher among those who had a stroke (42.1 per 1,000 pregnancy-related hospitalizations vs. 0.11 per 1,000 pregnancy-related hospitalizations; p < 0.0001). The rates of in-hospital mortality among pregnant women with acute stroke decreased (5.5% in 2007 vs. 2.7% in 2015; ptrends < 0.001). CONCLUSIONS In this contemporary analysis of pregnancy-related hospitalizations, acute stroke occurred in 1 of every 2,222 hospitalizations, and these rates did not decrease over approximately 9 years. The prevalence of most stroke risk factors has increased. Acute stroke during pregnancy and puerperium was associated with high maternal mortality, although it appears to be trending downward. Future studies to better identify mechanisms and approaches to prevention and management of acute stroke during pregnancy and puerperium are warranted.

中文翻译:

妊娠和产褥期急性中风

背景 怀孕期间或分娩后 6 周内的急性中风对母亲及其家人来说是毁灭性的,但关于发病率和当代趋势的数据非常有限。目的 本研究旨在通过大型数据库调查妊娠期间或分娩后 6 周内急性卒中和短暂性脑缺血发作的发生率和结局。方法 查询全国住院患者样本,以确定 2007 年 1 月 1 日至 2015 年 9 月 30 日期间在美国年龄≥18 岁且因妊娠相关住院的女性。急性卒中(缺血性和出血性)/短暂性脑缺血发作发生率的时间趋势和住院死亡率被提取出来。结果 在 37,360,772 次与妊娠相关的住院治疗中,16,694 名 (0.045%) 女性患有急性卒中。急性卒中的发生率没有变化(42. 2007 年每 100,000 人住院 8 人,而 2015 年每 100,000 人住院 42.2 人;趋势 = 0.10)。在急性卒中患者中,肥胖、吸烟、高脂血症、偏头痛和妊娠高血压的患病率增加。重要的是,中风患者的住院死亡率几乎高出 385 倍(每 1,000 次与妊娠相关的住院治疗中 42.1 次对每 1,000 次与妊娠相关的住院治疗中发生 0.11 次;p < 0.0001)。急性卒中孕妇的住院死亡率下降(2007 年为 5.5%,2015 年为 2.7%;趋势 < 0.001)。结论 在对妊娠相关住院的现代分析中,每 2,222 次住院治疗中就有 1 次发生急性卒中,并且这些发生率在大约 9 年内没有下降。大多数中风危险因素的患病率有所增加。妊娠和产褥期急性中风与高产妇死亡率有关,尽管它似乎呈下降趋势。未来的研究有必要更好地确定预防和管理妊娠和产褥期急性卒中的机制和方法。
更新日期:2020-01-01
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