RNA is produced from the majority of human genomic sequences, although only a relatively small portion of these transcripts has known functions. Diverse RNA species interact with RNA, DNA, proteins, lipids, and metabolites to form intricate molecular networks. In this review, we attempt to delineate diverse RNA functions by interaction types between RNA and other macromolecules. Through such interactions RNAs participate in essentially every major molecular function and process, including information flow and storage, environment sensing, signal transduction, and gene regulation at transcriptional and posttranscriptional levels. Through such interactions, RNAs promote or inhibit diverse biological processes, and act as catalyzer or quencher to modulate the pace of these progresses. Alterations and personal variations of these interactions are mechanistically coupled with disease etiology and phenotypical variations for clinical use.

中文翻译：

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RNA：相互作用驱动功能。

RNA 是由大多数人类基因组序列产生的，尽管这些转录物中只有相对一小部分具有已知的功能。不同的 RNA 种类与 RNA、DNA、蛋白质、脂质和代谢物相互作用，形成复杂的分子网络。在这篇综述中，我们试图通过 RNA 与其他大分子之间的相互作用类型来描述不同的 RNA 功能。通过这种相互作用，RNA 基本上参与每一个主要的分子功能和过程，包括信息流动和存储、环境感知、信号转导以及转录和转录后水平的基因调控。通过这种相互作用，RNA 促进或抑制多种生物过程，并充当催化剂或猝灭剂来调节这些进展的速度。这些相互作用的改变和个人差异在机械上与临床使用的疾病病因学和表型变异相关。