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Umpolung of Enamines: An Overview on Strategies and Synthons
Synlett ( IF 1.7 ) Pub Date : 2020-01-13 , DOI: 10.1055/s-0037-1610741 Alexey Yu. Sukhorukov 1, 2, 3
Synlett ( IF 1.7 ) Pub Date : 2020-01-13 , DOI: 10.1055/s-0037-1610741 Alexey Yu. Sukhorukov 1, 2, 3
Affiliation
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Umpolung strategies are of considerable interest to organic chemists because they provide alternative synthetic routes to those imposed by the natural polarity of classical synthons. Reverse-polarity reactions of aldehydes, α,β-unsaturated carbonyl compounds, and imines are deeply embedded in the methodology of organic synthesis. In recent years, umpolung of enols and enamines has received much attention as a novel strategy to access α-substituted ketones. Here, state-of-the-art approaches to umpolung of enamine reactivity are discussed, with a particular focus on recent developments in this field from the author’s research group. 1 Introduction 2 Approaches toward Umpolung of Enamines 3 Umpolung of Enamines through Single-Electron Oxidation 4 Azadienes as Synthetic Equivalents of Enamine Umpolung Synthons 5 Enamines Possessing a Leaving Group at the Nitrogen Atom 6 Enamines Possessing a Directing Group at the Nitrogen Atom 7 Summary and Outlook
中文翻译：
Enamines 的 Umpolung：策略和合成器概述
有机化学家对 Umpolung 策略相当感兴趣，因为它们为经典合成子的自然极性强加的那些提供了替代合成路线。醛、α,β-不饱和羰基化合物和亚胺的反极性反应深深植根于有机合成方法学中。近年来，烯醇和烯胺的 umpolung 作为一种获得 α 取代酮的新策略受到了广泛关注。在这里，讨论了对烯胺反应性进行 umpolung 的最先进方法，特别关注作者研究小组在该领域的最新发展。
更新日期：2020-01-13
中文翻译：
Enamines 的 Umpolung：策略和合成器概述
有机化学家对 Umpolung 策略相当感兴趣，因为它们为经典合成子的自然极性强加的那些提供了替代合成路线。醛、α,β-不饱和羰基化合物和亚胺的反极性反应深深植根于有机合成方法学中。近年来，烯醇和烯胺的 umpolung 作为一种获得 α 取代酮的新策略受到了广泛关注。在这里，讨论了对烯胺反应性进行 umpolung 的最先进方法，特别关注作者研究小组在该领域的最新发展。
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