The hazardous nature of molecular oxygen can be mitigated with the use of flow reactors of small size, which in turn accelerate the gas-to-liquid mass transfer rate. In this contribution, we describe a reconfigurable automated flow platform integrating on-line HPLC monitoring for the cobalt-catalyzed aerobic oxidative dimerization of desmethoxycarpacine to carpanone. The flow platform was configured for aerobic oxidation under either a gas–liquid segmented or tube-in-tube strategy. An extensive optimization study concluded that the tube-in-tube device was penalized by the use of expensive and fragile Teflon AF-2400 tubing while the gas–liquid segmented setup featured higher yields (62% vs 48%), shorter reaction times (5 min vs 20 min), and better robustness.

中文翻译：

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使用自动流动平台比较去甲氧基卡卡因有氧二聚体的气液分段和管内设置

分子氧的危险性可以通过使用小尺寸的流动反应器来减轻，这反过来又加快了气液传质速率。在此贡献中，我们描述了一种可重构的自动化流动平台，该平台整合了在线HPLC监测，以将脱甲氧基卡帕因钴催化的需氧氧化二聚化为甲酮。该流动平台配置为在气液分段或管中管策略下进行好氧氧化。一项广泛的优化研究得出的结论是，使用昂贵且易碎的Teflon AF-2400管对管中管装置不利，而气液分段装置的收​​率更高（62％比48％），反应时间更短（5分钟与20分钟），并且具有更好的鲁棒性。