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A pregnancy complication-dependent change in SIgA-targeted microbiota during third trimester.
Food & Function ( IF 5.1 ) Pub Date : 2020-01-29 , DOI: 10.1039/c9fo02919b Mengjun Cui 1 , Ce Qi 2 , Liping Yang 3 , Mengyun Zhang 4 , Huiyan Wang 3 , Guangtong She 5 , Renqiang Yu 6 , Tingting Miao 2 , Jin Sun 7
Food & Function ( IF 5.1 ) Pub Date : 2020-01-29 , DOI: 10.1039/c9fo02919b Mengjun Cui 1 , Ce Qi 2 , Liping Yang 3 , Mengyun Zhang 4 , Huiyan Wang 3 , Guangtong She 5 , Renqiang Yu 6 , Tingting Miao 2 , Jin Sun 7
Affiliation
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Gut microbiota play a crucial role in metabolic dysfunction during gestation, which might be prevented by using probiotics. This study compared the composition of the gut microbiota in healthy and complicated pregnancies, for screening and isolating healthy pregnancy-derived probiotics. According to the principal component analysis of secretory immunoglobulin A (SIgA)-coated microbiota in the gut, third-trimester volunteers can be divided into three groups: AHd (n = 29), GDMd (n = 37), and GHd (n = 25), dominated by asymptomatic healthy donors (62.07%), gestational diabetes mellitus (GDM) donors (40.54%), and gestational hypertension (GH) donors (40%), respectively. There was a significant difference in β-diversity (p < 0.01) and α-diversity (p < 0.05) among the three groups. At the phylum level, the Firmicutes of the GHd group were significantly lower than those of the AHd group (p = 0.039), while Bacteroidetes (p = 0.005) and Proteobacteria (p = 0.002) of the GHd group were more dominant than those of the AHd group. At the genus level, the linear discriminant analysis effect size showed that SIgA-targeted Enterococcus was the dominant taxonomic biomarker of the AHd group, and the GHd group was enriched with Escherichia and Streptococcus. The GDMd and GHd groups had higher faecal calprotectin, serum lipopolysaccharide, zonulin, and GLYCAM-1 levels. We conclude that the occurrence of complications in the third trimester may be related to intestinal barrier injury associated with disorders of the intestinal SIgA-targeted microbiota; gut barrier injury triggers inflammation in pregnant women. SIgA-targeted L. reuteri showed a significant correlation with low inflammatory response and may be a potential probiotic candidate for preventing pregnancy complications.
中文翻译：
在妊娠中期，妊娠并发症对SIgA靶向菌群的变化。
肠道菌群在妊娠期间的代谢功能障碍中起着至关重要的作用，这可以通过使用益生菌来预防。这项研究比较了健康和复杂妊娠中肠道菌群的组成，以筛选和分离健康的妊娠衍生益生菌。根据肠道内分泌免疫球蛋白A（SIgA）包裹的微生物群的主成分分析，孕晚期志愿者可分为三组：AHd（n = 29），GDMd（n = 37）和GHd（n = 25），分别由无症状的健康捐赠者（62.07％），妊娠糖尿病（GDM）捐赠者（40.54％）和妊娠高血压（GH）捐赠者（40％）占主导。三组之间的β多样性（p <0.01）和α多样性（p <0.05）存在显着差异。在门级，GHd组的菌毛明显低于AHd组（p = 0.039），而GHd组的拟杆菌属（p = 0.005）和Proteobacteria（p = 0.002）比AHd组更为显着。在属水平上，线性判别分析的效果大小表明，靶向SIgA的肠球菌是AHd组的主要分类生物标志物，而GHd组则富含埃希氏菌和链球菌。GDMd和GHd组的粪便钙卫蛋白，血清脂多糖，zonulin和GLYCAM-1水平较高。我们得出的结论是，在妊娠晚期并发症的发生可能与与肠SIgA靶向菌群失调相关的肠屏障损伤有关。肠屏障损伤可引发孕妇发炎。针对SIgA的L.
更新日期：2020-02-26
中文翻译：
在妊娠中期，妊娠并发症对SIgA靶向菌群的变化。
肠道菌群在妊娠期间的代谢功能障碍中起着至关重要的作用，这可以通过使用益生菌来预防。这项研究比较了健康和复杂妊娠中肠道菌群的组成，以筛选和分离健康的妊娠衍生益生菌。根据肠道内分泌免疫球蛋白A（SIgA）包裹的微生物群的主成分分析，孕晚期志愿者可分为三组：AHd（n = 29），GDMd（n = 37）和GHd（n = 25），分别由无症状的健康捐赠者（62.07％），妊娠糖尿病（GDM）捐赠者（40.54％）和妊娠高血压（GH）捐赠者（40％）占主导。三组之间的β多样性（p <0.01）和α多样性（p <0.05）存在显着差异。在门级，GHd组的菌毛明显低于AHd组（p = 0.039），而GHd组的拟杆菌属（p = 0.005）和Proteobacteria（p = 0.002）比AHd组更为显着。在属水平上，线性判别分析的效果大小表明，靶向SIgA的肠球菌是AHd组的主要分类生物标志物，而GHd组则富含埃希氏菌和链球菌。GDMd和GHd组的粪便钙卫蛋白，血清脂多糖，zonulin和GLYCAM-1水平较高。我们得出的结论是，在妊娠晚期并发症的发生可能与与肠SIgA靶向菌群失调相关的肠屏障损伤有关。肠屏障损伤可引发孕妇发炎。针对SIgA的L.
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